Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.62 |
| ▸ | PPARD | Q03181 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | NDUFS8 | O00217 | 1/20 | 0.52 |
| ▸ | COXFA4 | O00483 | 1/20 | 0.52 |
| ▸ | NDUFAB1 | O14561 | 1/20 | 0.52 |
| ▸ | NDUFA1 | O15239 | 1/20 | 0.52 |
| ▸ | NDUFS4 | O43181 | 1/20 | 0.52 |
| ▸ | NDUFB5 | O43674 | 1/20 | 0.52 |
| ▸ | NDUFB3 | O43676 | 1/20 | 0.52 |
| ▸ | NDUFC1 | O43677 | 1/20 | 0.52 |
| ▸ | NDUFA2 | O43678 | 1/20 | 0.52 |
| ▸ | NDUFS5 | O43920 | 1/20 | 0.52 |
| ▸ | NDUFS7 | O75251 | 1/20 | 0.52 |
| ▸ | NDUFS2 | O75306 | 1/20 | 0.52 |
| ▸ | NDUFS6 | O75380 | 1/20 | 0.52 |
| ▸ | NDUFB1 | O75438 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5088775 | 1.00 | TRPV1 (0.62) | TRPV1PPARDALOX15TDP1ALDH1A1 | |
| SCHEMBL7168649 | 0.99 | TRPV1 (0.60) | TRPV1PPARDALOX15TDP1ALDH1A1 | |
| SCHEMBL2670101 | 0.90 | TRPV1 (0.59) | TRPV1ALOX15TDP1ALDH1A1KDM4E | |
| SCHEMBL2670106 | 0.90 | TRPV1 (0.59) | TRPV1ALOX15TDP1ALDH1A1KDM4E | |
| SCHEMBL24723567 | 0.88 | TRPV1 (0.60) | TRPV1PPARDALOX15TDP1ALDH1A1 | |
| SCHEMBL5092438 | 0.88 | TRPV1 (0.60) | TRPV1PPARDALOX15TDP1ALDH1A1 | |
| SCHEMBL5092441 | 0.88 | TRPV1 (0.60) | TRPV1PPARDALOX15TDP1ALDH1A1 | |
| SCHEMBL31590280 | 0.87 | PPARD (0.61) | TRPV1PPARDALDH1A1KDM4ENDUFS8 | |
| SCHEMBL12039195 | 0.87 | TRPV1 (0.58) | TRPV1PPARDALOX15TDP1ALDH1A1 | |
| SCHEMBL5088847 | 0.87 | TRPV1 (0.70) | TRPV1ALOX15TDP1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7348017-B2 | Dithiazole compounds, matrix metalloprotease inhibitors and external preparations for the skin | SHISEIDO CO., LTD. (JP) | 2008-03-25 | — | — | US | disclosed |
| EP-1422224-B1 | DITHIAZOLE COMPOUNDS, MATRIX METALLOPROTEASE INHIBITORS AND EXTERNAL PREPARATIONS FOR THE SKIN | SHISEIDO CO LTD (JP) | 2007-12-19 | — | — | EP | disclosed |
| US-20040236111-A1 | Dithiazole compounds, matrix metalloprotease inhibitors and external preparations for the skin | SHISEIDO CO., LTD. (JP) | 2004-11-25 | — | — | US | disclosed |
| EP-1422224-A1 | DITHIAZOLE COMPOUNDS, MATRIX METALLOPROTEASE INHIBITORS AND EXTERNAL PREPARATIONS FOR THE SKIN | Shiseido Co., Ltd. (JP) | 2004-05-26 | — | — | EP | disclosed |
| EP-0736526-B1 | Pyrazolidine derivative, radical scavenger, brain-infarction depressant, and brain-edema depressant | SHISEIDO CO LTD (JP) | 2003-02-12 | — | — | EP | disclosed |
| US-5849930-A | Pyrazolidine derivative radical scavenger brain-infarction depressant and brain-edema depressant | SHISEIDO CO., LTD. (JP) | 1998-12-15 | — | — | US | disclosed |
| EP-0736526-A1 | Pyrazolidine derivative, radical scavenger, brain-infarction depressant, and brain-edema depressant | SHISEIDO COMPANY LIMITED (JP) | 1996-10-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040236111-A1 | Dithiazole compounds, matrix metalloprotease inhibitors and external preparations for the skin | MMP1, MMP2, MMP3 | TRPV1 1143/4885PPARD 2717/4885ALOX15 814/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.