Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 1/20 | 0.58 |
| ▸ | CHRM3 | P20309 | 8/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 7/20 | 0.53 |
| ▸ | ACHE | P22303 | 3/20 | 0.49 |
| ▸ | RAMP1 | O60894 | 2/20 | 0.48 |
| ▸ | CALCRL | Q16602 | 2/20 | 0.48 |
| ▸ | CTSS | P25774 | 4/20 | 0.47 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3596998 | 0.91 | CHRM4 (0.58) | CHRM4CHRM3CHRM2ACHERAMP1 | |
| SCHEMBL2980917 | 0.87 | CTSS (0.57) | CHRM4CHRM3CHRM2ACHECALCRL | |
| SCHEMBL9046543 | 0.86 | CHRM4 (0.70) | CHRM4CHRM3CHRM2ACHERAMP1 | |
| SCHEMBL5091174 | 0.84 | CHRM3 (0.58) | CHRM4CHRM3CHRM2ACHEDRD2 | |
| SCHEMBL3958065 | 0.83 | CHRM4 (0.56) | CHRM4CHRM3CHRM2ACHERAMP1 | |
| SCHEMBL3967246 | 0.82 | CHRM4 (0.65) | CHRM4CHRM3CHRM2ACHERAMP1 | |
| SCHEMBL4608265 | 0.81 | CHRM4 (0.55) | CHRM4CHRM3CHRM2RAMP1CALCRL | |
| SCHEMBL3960194 | 0.80 | CHRM4 (0.55) | CHRM4CHRM3CHRM2ACHECALCRL | |
| SCHEMBL4146115 | 0.78 | CHRM4 (0.55) | CHRM4CHRM3CHRM2ACHERAMP1 | |
| SCHEMBL3959945 | 0.77 | CHRM4 (0.55) | CHRM4CHRM3CHRM2ACHEDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7407963-B2 | Cyclopropane CGRP antagonists, medicaments containing these compounds, and method for the production thereof | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2008-08-05 | — | — | US | disclosed |
| US-20050267137-A1 | Cyclopropane CGRP antagonists, medicaments containing these compounds, and method for the production thereof | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2005-12-01 | — | — | US | disclosed |
| EP-1228059-B1 | NOVEL CYCLOPROPANES AS CGRP ANTAGONISTS, MEDICAMENTS CONTAINING SAID COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF | BOEHRINGER INGELHEIM PHARMA (DE) | 2005-08-03 | — | — | EP | disclosed |
| CN-1177844-C | Cyclopropanes as CGRP antagonists, medicaments contg. said compounds and method for production thereof | ���ָ��Ӣ��ķ�������Ϲ�˾ | 2004-12-01 | — | — | CN | disclosed |
| US-20030139417-A1 | Cyclopropane CGRP antagonists, medicaments containing these compounds, and method for the production thereof | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2003-07-24 | — | — | US | disclosed |
| CN-1387526-A | Cyclopropanes as CGRP antagonists, medicaments contg. said compounds and method for production thereof | BOEHRINGER INGELHEIM PHARMA (DE) | 2002-12-25 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050267137-A1 | Cyclopropane CGRP antagonists, medicaments containing these compounds, and method for the production thereof | CALCRL, CALCA, CALCR | CHRM4 660/4885CHRM3 386/4885CHRM2 318/4885 |
| US-20030139417-A1 | Cyclopropane CGRP antagonists, medicaments containing these compounds, and method for the production thereof | CALCA, CALCRL, CALCB | CHRM4 860/4885CHRM3 514/4885CHRM2 410/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.