Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 4/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.42 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | P2RY12 | Q9H244 | 3/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6565239 | 0.79 | PDE3B (0.49) | PDE3BPDE3AEGLN1ALDH1A1KMT2A | |
| SCHEMBL705929 | 0.79 | EGLN1 (0.62) | PDE3BPDE3AEGLN1 | |
| SCHEMBL22288463 | 0.77 | PDE3B (0.44) | PDE3BPDE3AEGLN1ALDH1A1KMT2A | |
| SCHEMBL27878745 | 0.76 | PDE3B (0.46) | PDE3BPDE3AEGLN1ALDH1A1KMT2A | |
| SCHEMBL6535849 | 0.68 | KDM4E (0.51) | PDE3BPDE3AALDH1A1HPGDHSD17B10 | |
| SCHEMBL8629707 | 0.66 | MCL1 (0.51) | PDE3BPDE3AALDH1A1KMT2AMCL1 | |
| SCHEMBL13310734 | 0.66 | PDE3B (0.46) | PDE3BPDE3AEGLN1ALDH1A1KMT2A | |
| SCHEMBL6565865 | 0.66 | EGLN1 (0.57) | EGLN1ALDH1A1HPGDPOLBKDM4E | |
| SCHEMBL6567169 | 0.66 | ALDH1A1 (0.52) | PDE3BPDE3AALDH1A1KMT2AMAPT | |
| SCHEMBL8628366 | 0.65 | MCL1 (0.47) | PDE3BPDE3AKMT2AMCL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919463-A2 | USE OF HIF 1ALFA MODULATORS FOR TREATMENT OF CANCER | FIBROGEN, INC. (US) | 2008-05-14 | — | — | EP | disclosed |
| WO-2006138511-A2 | USE OF HIF 1ALFA MODULATORS FOR TREATMENT OF CANCER | FIBROGEN, INC. (US) | 2006-12-28 | — | — | WO | disclosed |