Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | FDPS | P14324 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2870324 | 0.98 | OPRM1 (0.37) | OPRM1FDPSALDH1A1TDP1TSHR | |
| Iodide SCHEMBL5089313 | 0.95 | OPRM1 (0.36) | OPRM1FDPSALDH1A1TDP1TSHR | |
| Hydrochloric Acid SCHEMBL5087221 | 0.95 | OPRM1 (0.36) | OPRM1FDPSALDH1A1TDP1TSHR | |
| Water SCHEMBL3485695 | 0.95 | OPRM1 (0.36) | OPRM1FDPSALDH1A1TDP1TSHR | |
| Bromide SCHEMBL7508390 | 0.91 | DNM1 (0.39) | OPRM1FDPSTSHRDNM1SPHK1 | |
| SCHEMBL3309843 | 0.91 | OPRM1 (0.41) | OPRM1FDPSALDH1A1TDP1TSHR | |
| Bromide SCHEMBL5087068 | 0.89 | OPRM1 (0.44) | OPRM1FDPSDNM1CA1SPHK1 | |
| Hydrochloric Acid SCHEMBL11826394 | 0.89 | OPRM1 (0.39) | OPRM1FDPSALDH1A1TDP1TSHR | |
| SCHEMBL3311714 | 0.88 | OPRM1 (0.37) | OPRM1FDPSALDH1A1TDP1TSHR | |
| SCHEMBL3304504 | 0.88 | OPRM1 (0.37) | OPRM1FDPSALDH1A1TDP1SPHK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105452261-B | continuous process for preparing thiocarboxylate silane | 莫门蒂夫性能材料股份有限公司 | 2019-12-10 | — | — | CN | disclosed |
| EP-3019507-B1 | CONTINUOUS PROCESS FOR THE PREPARATION OF THIOCARBOXYLATE SILANE | MOMENTIVE PERFORMANCE MAT INC (US) | 2017-06-21 | — | — | EP | disclosed |
| US-9193742-B2 | Continuous process for the preparation of thiocarboxylate silane | MOMENTIVE PERFORMANCE MATERIALS INC. (US) | 2015-11-24 | — | — | US | disclosed |
| US-20150080595-A1 | CONTINUOUS PROCESS FOR THE PREPARATION OF THIOCARBOXYLATE SILANE | MOMENTIVE PERFORMANCE MATERIALS INC. | 2015-03-19 | — | — | US | disclosed |
| US-20080214386-A1 | Stability; easily separated from solution; surface treatment of catalyst with Group seven compound; reacting epoxide with carbon dioxide | NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) | 2008-09-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150080595-A1 | CONTINUOUS PROCESS FOR THE PREPARATION OF THIOCARBOXYLATE SILANE | TST, CTH, STS | OPRM1 3769/4885FDPS 175/4885ALDH1A1 249/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.