Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 6/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | DHODH | Q02127 | 1/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | PRNP | P04156 | 1/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5097673 | 0.94 | PLA2G2A (0.57) | PLA2G2AALDH1A1DHODHMMP13PRNP | |
| SCHEMBL5090505 | 0.89 | PLA2G2A (0.48) | PLA2G2AALDH1A1DHODHCYP11B1CYP11B2 | |
| SCHEMBL5097651 | 0.88 | PLA2G2A (0.53) | PLA2G2ADHODHPRNPMTNR1AMTNR1B | |
| SCHEMBL5093351 | 0.88 | PLA2G2A (0.48) | PLA2G2AALDH1A1DHODHPRNPKMT2A | |
| SCHEMBL31389258 | 0.87 | ALOX15 (0.52) | PLA2G2AMMP13MTNR1AMTNR1B | |
| SCHEMBL5098634 | 0.87 | PLA2G2A (0.47) | PLA2G2AALDH1A1DHODHPRNP | |
| SCHEMBL5097709 | 0.86 | PLA2G2A (0.47) | PLA2G2AALDH1A1DHODHKMT2A | |
| SCHEMBL5090515 | 0.86 | PLA2G2A (0.47) | PLA2G2AALDH1A1DHODHPRNPKMT2A | |
| SCHEMBL5090528 | 0.85 | PLA2G2A (0.43) | PLA2G2AALDH1A1DHODHFFAR4PDE4D | |
| SCHEMBL5093369 | 0.85 | PLA2G2A (0.45) | PLA2G2ADHODHCYP11B2PRNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7470708-B2 | Acidic quinoline derivatives and their use for the prevention and/or treatment of hyperglycaemia-related pathologies | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2008-12-30 | — | — | US | disclosed |
| US-7470708-B2 | Acidic quinoline derivatives and their use for the prevention and/or treatment of hyperglycaemia-related pathologies | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2008-12-30 | — | — | US | disclosed |
| US-7470708-B2 | Acidic quinoline derivatives and their use for the prevention and/or treatment of hyperglycaemia-related pathologies | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2008-12-30 | — | — | US | disclosed |