Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 4/20 | 0.53 |
| ▸ | DHODH | Q02127 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | PRNP | P04156 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5093351 | 0.91 | PLA2G2A (0.48) | PLA2G2ADHODHLMNAMAPTKDM4E | |
| SCHEMBL5088520 | 0.91 | ALOX15 (0.56) | PLA2G2ADHODHALOX15LMNANPSR1 | |
| SCHEMBL5090515 | 0.89 | PLA2G2A (0.47) | PLA2G2ADHODHALOX15MAPTKDM4E | |
| SCHEMBL5098634 | 0.88 | PLA2G2A (0.47) | PLA2G2ADHODHLMNAMAPTKDM4E | |
| SCHEMBL5091950 | 0.88 | PLA2G2A (0.58) | PLA2G2ADHODHMTNR1AMTNR1BPRNP | |
| SCHEMBL5097709 | 0.87 | PLA2G2A (0.47) | PLA2G2ADHODHMAPTKDM4ERAB9A | |
| SCHEMBL5088597 | 0.87 | PLA2G2A (0.45) | PLA2G2ADHODHLMNAMAPTKDM4E | |
| SCHEMBL5097673 | 0.87 | PLA2G2A (0.57) | PLA2G2ADHODHMAPTKDM4EMTNR1B | |
| SCHEMBL5093341 | 0.87 | MRGPRX4 (0.46) | PLA2G2ADHODHMAPTKDM4ERAB9A | |
| SCHEMBL5093369 | 0.86 | PLA2G2A (0.45) | PLA2G2ADHODHMAPTKDM4EPRNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7470708-B2 | Acidic quinoline derivatives and their use for the prevention and/or treatment of hyperglycaemia-related pathologies | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2008-12-30 | — | — | US | disclosed |
| US-7470708-B2 | Acidic quinoline derivatives and their use for the prevention and/or treatment of hyperglycaemia-related pathologies | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2008-12-30 | — | — | US | disclosed |
| US-7470708-B2 | Acidic quinoline derivatives and their use for the prevention and/or treatment of hyperglycaemia-related pathologies | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2008-12-30 | — | — | US | disclosed |