Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 7/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NCF1 | P14598 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.41 |
| ▸ | PPARD | Q03181 | 2/20 | 0.41 |
| ▸ | PPARA | Q07869 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5098637 | 0.90 | DHODH (0.46) | PDE10ADHODHMEN1KMT2ANCF1 | |
| SCHEMBL5088530 | 0.84 | DHODH (0.42) | ALOX15DHODHPPARGMAPTALDH1A1 | |
| SCHEMBL5088520 | 0.84 | ALOX15 (0.56) | PDE10AALOX15DHODHPOLBTDP1 | |
| SCHEMBL5097666 | 0.82 | PPARA (0.42) | ALOX15DHODHMEN1KMT2APPARG | |
| SCHEMBL5088569 | 0.81 | DHODH (0.45) | PDE10AALOX15DHODHKDM4EALDH1A1 | |
| SCHEMBL4649127 | 0.81 | ALOX15 (0.42) | PDE10AALOX15DHODHKDM4EGAA | |
| SCHEMBL5097600 | 0.81 | ALOX15 (0.42) | PDE10AALOX15DHODHKDM4EGAA | |
| SCHEMBL4620763 | 0.80 | PDE10A (0.52) | PDE10AALOX15DHODHMEN1KMT2A | |
| SCHEMBL5090505 | 0.80 | PLA2G2A (0.48) | PDE10AALOX15DHODHPPARGALDH1A1 | |
| SCHEMBL5098674 | 0.79 | PLA2G2A (0.47) | PDE10AALOX15DHODHKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7470708-B2 | Acidic quinoline derivatives and their use for the prevention and/or treatment of hyperglycaemia-related pathologies | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2008-12-30 | — | — | US | disclosed |
| US-7470708-B2 | Acidic quinoline derivatives and their use for the prevention and/or treatment of hyperglycaemia-related pathologies | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2008-12-30 | — | — | US | disclosed |
| US-7470708-B2 | Acidic quinoline derivatives and their use for the prevention and/or treatment of hyperglycaemia-related pathologies | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2008-12-30 | — | — | US | disclosed |