Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | DHODH | Q02127 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5097651 | 0.91 | PLA2G2A (0.53) | ALOX15PLA2G2ALMNAKDM4EDHODH | |
| SCHEMBL5090505 | 0.84 | PLA2G2A (0.48) | ALOX15ALDH1A1PLA2G2ADHODHPDE10A | |
| SCHEMBL5097666 | 0.84 | PPARA (0.42) | ALOX15ALDH1A1DHODHL3MBTL1TDP1 | |
| SCHEMBL5092001 | 0.84 | PDE10A (0.43) | ALOX15ALDH1A1KDM4EDHODHMAPT | |
| SCHEMBL5098674 | 0.83 | PLA2G2A (0.47) | ALOX15ALDH1A1PLA2G2AKDM4EDHODH | |
| SCHEMBL5088530 | 0.83 | DHODH (0.42) | ALOX15ALDH1A1DHODHMAPT | |
| SCHEMBL5088569 | 0.83 | DHODH (0.45) | ALOX15ALDH1A1KDM4EDHODHPDE10A | |
| SCHEMBL4649127 | 0.83 | ALOX15 (0.42) | ALOX15ALDH1A1KDM4EDHODHPDE10A | |
| SCHEMBL5097600 | 0.83 | ALOX15 (0.42) | ALOX15ALDH1A1KDM4EDHODHPDE10A | |
| SCHEMBL4620763 | 0.82 | PDE10A (0.52) | ALOX15ALDH1A1KDM4EDHODHSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7470708-B2 | Acidic quinoline derivatives and their use for the prevention and/or treatment of hyperglycaemia-related pathologies | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2008-12-30 | — | — | US | disclosed |
| US-7470708-B2 | Acidic quinoline derivatives and their use for the prevention and/or treatment of hyperglycaemia-related pathologies | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2008-12-30 | — | — | US | disclosed |
| US-7470708-B2 | Acidic quinoline derivatives and their use for the prevention and/or treatment of hyperglycaemia-related pathologies | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2008-12-30 | — | — | US | disclosed |