Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4733455 | 0.81 | CYP19A1 (0.53) | KCNH2CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL509920 | 0.74 | HDAC6 (0.41) | — | |
| SCHEMBL7070749 | 0.70 | SMN1; SMN2 (0.50) | KCNH2CYP19A1 | |
| Hydrochloric Acid SCHEMBL2450441 | 0.69 | — | — | |
| SCHEMBL28096086 | 0.69 | — | — | |
| SCHEMBL7074972 | 0.68 | EPAS1 (0.44) | — | |
| SCHEMBL7077215 | 0.68 | GRM5 (0.40) | KCNH2CYP19A1 | |
| SCHEMBL6169112 | 0.68 | ALDH1A1 (0.38) | CYP19A1KDM4C | |
| SCHEMBL7069974 | 0.67 | PDE4A (0.50) | CYP19A1 | |
| SCHEMBL29619624 | 0.67 | ALDH1A1 (0.58) | CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120029192-A1 | Pyrazole Derivatives | PFIZER INC | 2012-02-02 | — | — | US | disclosed |
| EP-1542679-B1 | 4-(3,5-DICYANOPHENOXY) PYRAZOLE DERIVATIVES FOR USE AS TRANSCRIPTASE MODULATORS IN THE TREATMENT OF I.A. HIV | PFIZER LTD (GB) | 2007-01-17 | — | — | EP | disclosed |
| CN-1681494-A | 4- (3, 5-dicyano-phenoxy) pyrazole derivatives as reverse transcriptase modulators in the treatment of i.a.hiv | PFIZER (US) | 2005-10-12 | — | — | CN | disclosed |
| EP-1542679-A1 | 4-(3,5-DICYANOPHENOXY) PYRAZOLE DERIVATIVES FOR USE AS TRANSCRIPTASE MODULATORS IN THE TREATMENT OF I.A. HIV | Pfizer Limited (GB) | 2005-06-22 | — | — | EP | disclosed |
| EP-1542679-A1 | 4-(3,5-DICYANOPHENOXY) PYRAZOLE DERIVATIVES FOR USE AS TRANSCRIPTASE MODULATORS IN THE TREATMENT OF I.A. HIV | Pfizer Limited (GB) | 2005-06-22 | — | — | EP | disclosed |
| WO-2004024147-A1 | 4-(3,5-DICYANOPHENOXY) PYRAZOLE DERIVATIVES FOR USE AS TRANSCRIPTASE MODULATORS IN THE TREATMENT OF I.A. HIV | PFIZER LIMITED (GB) | 2004-03-25 | — | — | WO | disclosed |
| WO-2004024147-A1 | 4-(3,5-DICYANOPHENOXY) PYRAZOLE DERIVATIVES FOR USE AS TRANSCRIPTASE MODULATORS IN THE TREATMENT OF I.A. HIV | PFIZER LIMITED (GB) | 2004-03-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120029192-A1 | Pyrazole Derivatives | POLRMT, PDCD11, DPYD | KCNH2 3548/4885CYP19A1 1179/4885CYP11B1 417/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.