Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 4/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | PTGES | O14684 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | CASP3 | P42574 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PRNP | P04156 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TNF | P01375 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4621902 | 0.90 | ALOX15 (0.42) | PLA2G2ADHODHPTGESKDM4EIDO1 | |
| SCHEMBL4622296 | 0.87 | PLA2G2A (0.44) | PLA2G2ADHODHKDM4ECASP3HSD17B10 | |
| SCHEMBL5704026 | 0.86 | ALDH1A1 (0.40) | PLA2G2ADHODHPTGESKDM4EIDO1 | |
| SCHEMBL5704033 | 0.86 | ALDH1A1 (0.40) | PLA2G2ADHODHPTGESKDM4EIDO1 | |
| SCHEMBL4620316 | 0.84 | PLA2G2A (0.47) | PLA2G2ADHODHKDM4ECASP3HSD17B10 | |
| SCHEMBL5093345 | 0.84 | PLA2G2A (0.45) | PLA2G2ADHODHKDM4ECASP3HSD17B10 | |
| SCHEMBL5093348 | 0.82 | PKM (0.44) | PLA2G2ADHODHKDM4EPRNPMEN1 | |
| SCHEMBL5090548 | 0.82 | PLA2G2A (0.43) | PLA2G2ADHODHKDM4ECASP3HSD17B10 | |
| SCHEMBL5093369 | 0.81 | PLA2G2A (0.45) | PLA2G2ADHODHKDM4ECASP3HSD17B10 | |
| SCHEMBL4621671 | 0.81 | PLA2G2A (0.45) | PLA2G2ADHODHKDM4ECASP3HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7470708-B2 | Acidic quinoline derivatives and their use for the prevention and/or treatment of hyperglycaemia-related pathologies | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2008-12-30 | — | — | US | disclosed |