Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | DPP4 | P27487 | 2/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.43 |
| ▸ | CCR6 | P51684 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.43 |
| ▸ | TTR | P02766 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | KDM4A | O75164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3173753 | 0.89 | ALDH1A1 (0.50) | STAT3RAB9ALMNAALDH1A1DPP4 | |
| SCHEMBL3173742 | 0.89 | ALDH1A1 (0.50) | STAT3RAB9ALMNAALDH1A1DPP4 | |
| SCHEMBL3159026 | 0.89 | RAB9A (0.48) | STAT3RAB9ALMNAALDH1A1EGFR | |
| SCHEMBL3159031 | 0.89 | RAB9A (0.48) | STAT3RAB9ALMNAALDH1A1EGFR | |
| SCHEMBL8806241 | 0.86 | STAT3 (0.43) | STAT3RAB9ALMNAALDH1A1EGFR | |
| SCHEMBL8806236 | 0.86 | STAT3 (0.43) | STAT3RAB9ALMNAALDH1A1EGFR | |
| SCHEMBL6171625 | 0.86 | DPP4 (0.46) | STAT3RAB9ALMNAALDH1A1AKR1B1 | |
| SCHEMBL6171630 | 0.86 | DPP4 (0.46) | STAT3RAB9ALMNAALDH1A1AKR1B1 | |
| SCHEMBL4876757 | 0.85 | STAT3 (0.52) | STAT3RAB9ALMNAALDH1A1EGFR | |
| SCHEMBL4876750 | 0.85 | STAT3 (0.52) | STAT3RAB9ALMNAALDH1A1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7339059-B2 | Benzofurans and indols | ACTIVE BIOTECH AB (SE) | 2008-03-04 | — | — | US | disclosed |
| US-20050192288-A1 | Benzofuran-2-yl-carbonyl- and indol-2-yl-carbonyl-trans-2,5-dimethyl-piperazine derivatives; rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, inflammatory bowel disease, asthma; inhibit the interaction between inflammatory chemokines and their receptor | ACTIVE BIOTECH AB (SE) | 2005-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050192288-A1 | Benzofuran-2-yl-carbonyl- and indol-2-yl-carbonyl-trans-2,5-dimethyl-piperazine derivatives; rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, inflammatory bowel disease, asthma; inhibit the interaction between inflammatory chemokines and their receptor | CXCR1, CCR2, CXCR5 | STAT3 128/4885RAB9A 2710/4885LMNA 2564/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.