Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 7/20 | 0.45 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | CFTR | P13569 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | CTSD | P07339 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5103547 | 0.91 | KIF11 (0.46) | KIF11MAP1LC3BCYP3A4CYP2C19KCNH2 | |
| SCHEMBL14078088 | 0.86 | KIF11 (0.58) | KIF11MAP1LC3BCYP3A4CYP2C19KCNH2 | |
| SCHEMBL4619180 | 0.86 | KIF11 (0.58) | KIF11MAP1LC3BCYP3A4CYP2C19KCNH2 | |
| SCHEMBL4620950 | 0.84 | KIF11 (0.44) | KIF11MAP1LC3BCYP3A4CYP2C19KCNH2 | |
| SCHEMBL14078131 | 0.84 | CFTR (0.43) | KIF11MAP1LC3BCYP3A4CYP2C19KCNH2 | |
| SCHEMBL14078144 | 0.82 | CTSK (0.42) | KIF11MAP1LC3BCYP3A4CYP2C19KCNH2 | |
| SCHEMBL4620824 | 0.81 | HDAC1 (0.45) | KIF11MAP1LC3BCYP3A4CYP2C19KCNH2 | |
| SCHEMBL4620627 | 0.80 | TACR1 (0.42) | KIF11MAP1LC3BCYP3A4CYP2C19KCNH2 | |
| SCHEMBL4620089 | 0.79 | LMNA (0.40) | KIF11MAP1LC3BCYP3A4CYP2C19KCNH2 | |
| SCHEMBL4619232 | 0.79 | KIF11 (0.44) | KIF11MAP1LC3BCYP3A4CYP2C19KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080234299-A1 | Quinazolinones | MERCK PATENT GMBH (DE) | 2008-09-25 | — | — | US | claimed |
| US-20080234299-A1 | Quinazolinones | MERCK PATENT GMBH (DE) | 2008-09-25 | — | — | US | disclosed |
| US-20080234299-A1 | Quinazolinones | MERCK PATENT GMBH (DE) | 2008-09-25 | — | — | US | disclosed |
| US-20080234299-A1 | Quinazolinones | MERCK PATENT GMBH (DE) | 2008-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234299-A1 | Quinazolinones | H1-3, NDUFS3, CCNT1 | KIF11 2324/4885MAP1LC3B 2831/4885CYP3A4 755/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.