Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGA4 | P13612 | 3/20 | 0.36 |
| ▸ | ITGB7 | P26010 | 3/20 | 0.36 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.32 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.32 |
| ▸ | BRD9 | Q9H8M2 | 7/20 | 0.31 |
| ▸ | BRD4 | O60885 | 6/20 | 0.31 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | MTOR | P42345 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL466423 | 0.75 | BRD4 (0.42) | ITGA4ITGB7ITGB1BRD9BRD4 | |
| SCHEMBL10288222 | 0.75 | LMNA (0.33) | ESR1ESR2HSPA5MAPTALDH1A1 | |
| SCHEMBL510385 | 0.73 | ACLY (0.35) | ITGA4ITGB7ITGB1BRD9BRD4 | |
| SCHEMBL15333888 | 0.72 | IDO1 (0.35) | ESR1ESR2HSPA5 | |
| SCHEMBL15334330 | 0.71 | KDM4C (0.34) | HSPA5 | |
| SCHEMBL15334271 | 0.71 | CTSK (0.31) | HSPA5 | |
| SCHEMBL10288372 | 0.71 | NPC1 (0.34) | HSPA5MAPTPKMALDH1A1 | |
| SCHEMBL15086653 | 0.70 | SMN1; SMN2 (0.34) | MAPTALDH1A1NPSR1 | |
| SCHEMBL15344238 | 0.69 | MEN1 (0.32) | GAA | |
| SCHEMBL15334387 | 0.69 | MEN1 (0.32) | GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8507410-B2 | Pyridazinone compound and use thereof | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2013-08-13 | — | — | US | disclosed |
| CN-102421759-A | Pyridazinone compounds and use thereof | SUMITOMO CHEMICAL CO | 2012-04-18 | — | — | CN | disclosed |
| US-20120028803-A1 | PYRIDAZINONE COMPOUND AND USE THEREOF | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2012-02-02 | — | — | US | disclosed |
| EP-2406232-A1 | PYRIDAZINONE COMPOUND AND USE THEREOF | Sumitomo Chemical Company, Limited (JP) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010104217-A1 | PYRIDAZINONE COMPOUND AND USE THEREOF | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2010-09-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028803-A1 | PYRIDAZINONE COMPOUND AND USE THEREOF | C5, C1S, WEE1 | ITGA4 2718/4885ITGB7 1974/4885ITGB1 1365/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.