SCHEMBL466423

SCHEMBL466423

CCc1ccccc1-c1c(O)cnn(C)c1=O

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 6/20 0.42
BRD9 Q9H8M2 5/20 0.42
ANPEP P15144 1/20 0.40
DPP4 P27487 1/20 0.40
HIF1A Q16665 1/20 0.40
PTGS2 P35354 1/20 0.39
BRPF1 P55201 1/20 0.39
KAT2B Q92831 3/20 0.39
BPTF Q12830 1/20 0.39
ITGA4 P13612 2/20 0.38
ITGB7 P26010 2/20 0.38
ITGB1 P05556 1/20 0.38
GAA P10253 1/20 0.38
MAPT P10636 1/20 0.38
PKM P14618 1/20 0.38
CASR P41180 2/20 0.38
PTGS1 P23219 1/20 0.38
LMNA P02545 2/20 0.36
HPGD P15428 1/20 0.36
MAPK1 P28482 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11910054 0.82 F7 (0.44) BRD4BRD9HIF1APTGS2KAT2B
SCHEMBL466422 0.80 ITGA4 (0.42) BRD4BRD9HIF1AITGA4ITGB7
SCHEMBL466444 0.76 KMT2A (0.43) BRD4BRD9ITGA4ITGB7ITGB1
SCHEMBL509686 0.75 ITGA4 (0.36) BRD4BRD9BRPF1KAT2BITGA4
SCHEMBL11965002 0.70 PTGS2 (0.38) BRD4HIF1APTGS2GAAMAPT
SCHEMBL11903442 0.70 MAPT (0.44) DPP4ITGA4ITGB7ITGB1MAPT
SCHEMBL11965001 0.70 LMNA (0.41) BRD4PTGS2GAAMAPTLMNA
SCHEMBL9956957 0.69 HIF1A (0.41) BRD4BRD9HIF1AGAAPKM
SCHEMBL11018106 0.69 ANPEP (0.54) ANPEPDPP4KAT2BMAPTLMNA
SCHEMBL980892 0.66 GABRA1 (0.50) ANPEPDPP4HIF1ALMNAHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9096534-B2 Pyridazinone compound and use thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2015-08-04 US disclosed
US-9096533-B2 Pyridazinone compound and use thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2015-08-04 US disclosed
US-20150126738-A1 PYRIDAZINONE COMPOUND AND USE THEREOF SUMITOMO CHEMICAL CO (JP) 2015-05-07 US disclosed
US-20150126739-A1 PYRIDAZINONE COMPOUND AND USE THEREOF SUMITOMO CHEMICAL CO (JP) 2015-05-07 US disclosed
US-8962625-B2 Pyridazinone compound and use thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2015-02-24 US disclosed
US-8541414-B2 Pyridazinone compound and use thereof as herbicides SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2013-09-24 US disclosed
US-20120196750-A1 PYRIDAZINONE COMPOUND AND USE THEREOF KIJI TOSHIYUKI (JP) 2012-08-02 US disclosed
CN-102421286-A Herbicidal composition SUMITOMO CHEMICAL CO 2012-04-18 CN disclosed
US-20120028988-A1 USE OF PYRIDAZINONE COMPOUND FOR CONTROL OF HARMFUL ARTHROPOD PESTS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-02-02 US disclosed
EP-2405745-A1 HERBICIDAL COMPOSITION Sumitomo Chemical Company, Limited (JP) 2012-01-18 EP disclosed
WO-2010104216-A1 HERBICIDAL COMPOSITION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-09-16 WO disclosed
US-20100210462-A1 HERBICIDAL COMPOSITION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-08-19 US disclosed
EP-2187745-A2 HERBICIDAL COMPOSITION Sumitomo Chemical Company, Limited (JP) 2010-05-26 EP disclosed
EP-2187744-A2 HERBICIDAL COMPOSITION COMPRISING A PYRIDAZINONE COMPOUND WITH A SPECIFIC HERBICIDE AND A SPECIFIC SAFENER Sumitomo Chemical Company, Limited (JP) 2010-05-26 EP disclosed
EP-1996557-B1 PYRIDAZINONE COMPOUND AND USE THEREOF AS HERBICIDES SUMITOMO CHEMICAL CO (JP) 2010-03-03 EP disclosed
CN-101443317-A Pyridazinone compound and herbicide containing the same SUMITOMO CHEMICAL CO (JP) 2009-05-27 CN disclosed
US-20090111696-A1 Pyridazinone Compound and Use Thereof as herbicides SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-04-30 US disclosed
WO-2009035145-A2 HERBICIDAL COMPOSITION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-03-19 WO disclosed
WO-2009035151-A2 HERBICIDAL COMPOSITION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-03-19 WO disclosed
WO-2009035146-A2 HERBICIDAL COMPOSITION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-03-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150126738-A1 PYRIDAZINONE COMPOUND AND USE THEREOF PDXK, PLPBP, PNPO BRD4 1708/4885BRD9 1164/4885ANPEP 1616/4885
US-20100210462-A1 HERBICIDAL COMPOSITION WEE1, WEE2, H1-3 BRD4 1240/4885BRD9 1854/4885ANPEP 1279/4885
US-20120028988-A1 USE OF PYRIDAZINONE COMPOUND FOR CONTROL OF HARMFUL ARTHROPOD PESTS PLPBP, PNPO, PIR BRD4 3219/4885BRD9 3557/4885ANPEP 2418/4885
US-20150126739-A1 PYRIDAZINONE COMPOUND AND USE THEREOF PDXK, PLPBP, PNPO BRD4 1708/4885BRD9 1164/4885ANPEP 1616/4885
US-20120196750-A1 PYRIDAZINONE COMPOUND AND USE THEREOF PDXK, PLPBP, PNPO BRD4 1708/4885BRD9 1164/4885ANPEP 1616/4885
US-20090111696-A1 Pyridazinone Compound and Use Thereof as herbicides PDXK, DDT, PLPBP BRD4 1357/4885BRD9 1225/4885ANPEP 1534/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.