Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | AXL | P30530 | 2/20 | 0.43 |
| ▸ | CASP3 | P42574 | 2/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5090503 | 0.87 | PLA2G2A (0.51) | PLA2G2ARAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL5091911 | 0.84 | NPC1 (0.53) | PLA2G2ARAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL5093348 | 0.82 | PKM (0.44) | PLA2G2ARAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL5097655 | 0.82 | MAPT (0.46) | PLA2G2ASMN1; SMN2KMT2AMAPTMEN1 | |
| SCHEMBL5093320 | 0.82 | PLA2G2A (0.49) | PLA2G2ANPC1SMN1; SMN2MAPTL3MBTL1 | |
| SCHEMBL5088547 | 0.81 | PLA2G2A (0.47) | PLA2G2ARAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL5093345 | 0.80 | PLA2G2A (0.45) | PLA2G2ASMN1; SMN2KCNH2CASP3 | |
| SCHEMBL5097671 | 0.80 | RECQL (0.46) | PLA2G2ARAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL5097709 | 0.79 | PLA2G2A (0.47) | PLA2G2ARAB9AKMT2AMAPTMEN1 | |
| SCHEMBL5091959 | 0.79 | PLA2G2A (0.45) | PLA2G2ARAB9ANPC1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7470708-B2 | Acidic quinoline derivatives and their use for the prevention and/or treatment of hyperglycaemia-related pathologies | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2008-12-30 | — | — | US | disclosed |
| US-7470708-B2 | Acidic quinoline derivatives and their use for the prevention and/or treatment of hyperglycaemia-related pathologies | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2008-12-30 | — | — | US | disclosed |
| US-7470708-B2 | Acidic quinoline derivatives and their use for the prevention and/or treatment of hyperglycaemia-related pathologies | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2008-12-30 | — | — | US | disclosed |