Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1052239 | 0.70 | CES1 (0.36) | NR1H2NR1H3ALDH1A1TSHRESR1 | |
| SCHEMBL913097 | 0.67 | ESR1 (0.32) | ALDH1A1TSHRESR1ESR2 | |
| SCHEMBL9900193 | 0.67 | ESR1 (0.32) | ALDH1A1TSHRESR1ESR2 | |
| SCHEMBL28427359 | 0.67 | ESR1 (0.32) | ALDH1A1TSHRESR1ESR2 | |
| SCHEMBL1049841 | 0.67 | ALDH1A1 (0.41) | NR1H2NR1H3ALDH1A1TSHRESR1 | |
| SCHEMBL1051334 | 0.67 | ALDH1A1 (0.41) | NR1H2NR1H3ALDH1A1TSHRESR1 | |
| SCHEMBL1053231 | 0.67 | ALDH1A1 (0.41) | NR1H2NR1H3ALDH1A1TSHRESR1 | |
| Methane SCHEMBL2931201 | 0.65 | ESR1 (0.31) | TSHRESR1ESR2 | |
| Methane SCHEMBL134744 | 0.65 | ESR1 (0.31) | TSHRESR1ESR2 | |
| SCHEMBL31318429 | 0.64 | MAPK1 (0.34) | ALDH1A1ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9725326-B2 | Hydrophilic silica as filler for silicone rubber formulations | EVONIK DEGUSSA GMBH (DE) | 2017-08-08 | — | — | US | disclosed |
| EP-2448865-B1 | HYDROPHILIC SILICA AS FILLER FOR SILICONE RUBBER FORMULATIONS | EVONIK DEGUSSA GMBH (DE) | 2016-09-21 | — | — | EP | disclosed |
| EP-2448865-A1 | HYDROPHILIC SILICA AS FILLER FOR SILICONE RUBBER FORMULATIONS | Evonik Degussa GmbH (DE) | 2012-05-09 | — | — | EP | disclosed |
| US-20120029136-A1 | HYDROPHILIC SILICA AS FILLER FOR SILICONE RUBBER FORMULATIONS | EVONIK DEGUSSA GMBH (DE) | 2012-02-02 | — | — | US | disclosed |
| WO-2011000133-A1 | HYDROPHILIC SILICA AS FILLER FOR SILICONE RUBBER FORMULATIONS | EVONIK DEGUSSA GMBH (DE) | 2011-01-06 | — | — | WO | disclosed |
| US-6846865-B2 | Silicone rubber formulations with hydrophobic silicas | DEGUSSA AG (DE) | 2005-01-25 | — | — | US | disclosed |
| US-20030181565-A1 | Silicone rubber formulations with hydrophobic silicas | DEGUSSA AG (DE) | 2003-09-25 | — | — | US | disclosed |
| US-4360388-A | Cerium containing precipitated silica, process for its production | DEGUSSA AKTIENGESELLSCHAFT (DE) | 1982-11-23 | — | — | US | disclosed |
| US-4308074-A | TREATING WITH HYDROPHOBIC AGENT | DEUTSCHE GOLD- UND SILBER-SCHEIDEANSTALT VORMALS ROESSLER (DE) | 1981-12-29 | — | — | US | disclosed |
| US-4273589-A | HYDROPHOBIC, REINFORCING FILLER FOR ELASTOMER | DEUTSCHE GOLD- UND SILBER-SCHEIDEANSTALT VORMALS ROESSLER (DE) | 1981-06-16 | — | — | US | disclosed |
| US-4208316-A | REINFORCING FILLER HARDENABLE ELASTOMERS | DEUTSCHE GOLD- UND SILBER-SCHEIDEANSTALT VORMALS ROESSLER (DE) | 1980-06-17 | — | — | US | disclosed |