Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YAP1 | P46937 | 3/20 | 0.52 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | STS | P08842 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | CCR1 | P32246 | 1/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 6/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5099423 | 1.00 | YAP1 (0.52) | YAP1GPR119KDM4EPKML3MBTL1 | |
| SCHEMBL5099437 | 1.00 | YAP1 (0.52) | YAP1GPR119KDM4EPKML3MBTL1 | |
| SCHEMBL5096543 | 0.87 | YAP1 (0.50) | YAP1GPR119KDM4EPKML3MBTL1 | |
| SCHEMBL5092573 | 0.85 | CTSK (0.46) | SMN1; SMN2MEN1ALDH1A1POLBMAPK1 | |
| SCHEMBL5569616 | 0.82 | YAP1 (0.55) | YAP1GPR119KDM4EPKML3MBTL1 | |
| SCHEMBL12249924 | 0.81 | YAP1 (0.62) | YAP1GPR119KDM4EPKML3MBTL1 | |
| SCHEMBL2999882 | 0.81 | YAP1 (0.62) | YAP1KDM4EPKMHTTNPC1 | |
| SCHEMBL8147986 | 0.81 | YAP1 (0.62) | YAP1KDM4EPKMHTTNPC1 | |
| SCHEMBL2999886 | 0.81 | YAP1 (0.62) | YAP1KDM4EPKMHTTNPC1 | |
| SCHEMBL18822510 | 0.81 | YAP1 (0.62) | YAP1GPR119KDM4EPKML3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7427632-B2 | Factor Xa inhibitors | ELI LILLY AND COMPANY (US) | 2008-09-23 | — | — | US | disclosed |
| US-20060052606-A1 | Factor xa Inhibitors | ELI LILLY AND COMPANY | 2006-03-09 | — | — | US | disclosed |
| EP-1581493-A1 | FACTOR XA INHIBITORS | ELI LILLY AND COMPANY (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004060872-A1 | FACTOR XA INHIBITORS | ELI LILLY AND COMPANY (US) | 2004-07-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060052606-A1 | Factor xa Inhibitors | F12, F11, SERPINC1 | YAP1 3400/4885GPR119 2769/4885KDM4E 2994/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.