Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CARM1 | Q86X55 | 20/20 | 0.65 |
| ▸ | PRMT6 | Q96LA8 | 20/20 | 0.65 |
| ▸ | PRMT8 | Q9NR22 | 3/20 | 0.52 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9703858 | 0.85 | CARM1 (0.74) | CARM1PRMT6PRMT8TMEM97SIGMAR1 | |
| Hydrochloric Acid SCHEMBL9556188 | 0.84 | CARM1 (0.72) | CARM1PRMT6PRMT8TMEM97SIGMAR1 | |
| SCHEMBL7186721 | 0.84 | CARM1 (0.45) | CARM1PRMT6HRH3 | |
| SCHEMBL5099023 | 0.83 | HRH3 (0.44) | CARM1PRMT6PRMT8HRH3PRMT3 | |
| SCHEMBL5102691 | 0.83 | HRH3 (0.50) | CARM1PRMT6HRH3 | |
| SCHEMBL5109440 | 0.81 | CCR3 (0.45) | CARM1PRMT6HRH3 | |
| SCHEMBL10077964 | 0.80 | HRH3 (0.54) | HRH3 | |
| SCHEMBL5098799 | 0.80 | CCR3 (0.48) | CARM1PRMT6HRH3 | |
| SCHEMBL5658226 | 0.80 | DRD2 (0.49) | CARM1PRMT6HRH3 | |
| SCHEMBL12342532 | 0.77 | CARM1 (0.74) | CARM1PRMT6PRMT8TMEM97SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7348341-B2 | Chemical compounds | ASTRAZENECA AB (SE) | 2008-03-25 | — | — | US | disclosed |
| US-7304077-B2 | Chemical compounds | ASTRAZENECA AB (SE) | 2007-12-04 | — | — | US | disclosed |
| US-20040102432-A1 | Chemical compounds | ASTRAZENECA AB (SE) | 2004-05-27 | — | — | US | disclosed |
| US-20030166652-A1 | Chemical compounds | ASTRAZENECA AB (SE) | 2003-09-04 | — | — | US | disclosed |
| EP-1322611-A1 | CHEMICAL COMPOUNDS | AstraZeneca AB (SE) | 2003-07-02 | — | — | EP | disclosed |
| EP-1289956-A1 | CHEMICAL COMPOUNDS | AstraZeneca AB (SE) | 2003-03-12 | — | — | EP | disclosed |
| WO-2002020484-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2002-03-14 | — | — | WO | disclosed |
| WO-2001092227-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2001-12-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030166652-A1 | Chemical compounds | CCR3, CCR1, CCR4 | CARM1 294/4885PRMT6 1084/4885PRMT8 1449/4885 |
| US-20040102432-A1 | Chemical compounds | CCL11, HRH1, HRH4 | CARM1 2185/4885PRMT6 1651/4885PRMT8 1686/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.