Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 5/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 5/20 | 0.46 |
| ▸ | HTR7 | P34969 | 4/20 | 0.46 |
| ▸ | HTR6 | P50406 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | PRKCQ | Q04759 | 5/20 | 0.45 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.45 |
| ▸ | PRKCB | P05771 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | PRKCH | P24723 | 1/20 | 0.44 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | GOT1 | P17174 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5117069 | 0.82 | DRD2 (0.47) | DRD2DRD4DRD3HTR2AGAA | |
| SCHEMBL5125845 | 0.80 | DRD2 (0.53) | DRD2DRD4DRD3HTR2AGAA | |
| SCHEMBL5117266 | 0.80 | GAA (0.53) | DRD2DRD4DRD3HTR2AGAA | |
| SCHEMBL5123496 | 0.80 | DRD2 (0.50) | DRD2DRD4DRD3HTR2AGAA | |
| Hydrochloric Acid SCHEMBL29046802 | 0.79 | DRD2 (0.52) | DRD2DRD4DRD3HTR2AGAA | |
| SCHEMBL2162517 | 0.77 | DRD2 (0.64) | DRD2DRD4DRD3HTR2AGAA | |
| SCHEMBL5124763 | 0.76 | GAA (0.43) | DRD2DRD4DRD3HTR2AGAA | |
| SCHEMBL7090551 | 0.76 | GAA (0.58) | DRD2DRD4DRD3HTR2AGAA | |
| SCHEMBL29046790 | 0.75 | DRD2 (0.54) | DRD2DRD4DRD3HTR2AGAA | |
| SCHEMBL30610349 | 0.75 | DRD2 (0.54) | DRD2DRD4DRD3HTR2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7342015-B2 | Indole derivatives | H. LUNDBECK A/S (DK) | 2008-03-11 | — | — | US | claimed |
| US-20060258678-A1 | Novel indole derivatives | H. LUNDBECK A/S (DK) | 2006-11-16 | — | — | US | claimed |
| EP-1399434-B1 | NOVEL INDOLE DERIVATIVES | LUNDBECK & CO AS H (DK) | 2005-09-07 | — | — | EP | claimed |
| US-7342015-B2 | Indole derivatives | H. LUNDBECK A/S (DK) | 2008-03-11 | — | — | US | disclosed |
| US-20060258678-A1 | Novel indole derivatives | H. LUNDBECK A/S (DK) | 2006-11-16 | — | — | US | disclosed |
| EP-1399434-B1 | NOVEL INDOLE DERIVATIVES | LUNDBECK & CO AS H (DK) | 2005-09-07 | — | — | EP | disclosed |
| EP-1399434-A1 | NOVEL INDOLE DERIVATIVES | H. Lundbeck A/S (DK) | 2004-03-24 | — | — | EP | disclosed |
| WO-2003002552-A1 | NOVEL INDOLE DERIVATIVES | H. LUNDBECK A/S (DK) | 2003-01-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060258678-A1 | Novel indole derivatives | IDO1, TPH1, HTR5A | DRD2 14/4885DRD4 20/4885DRD3 25/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.