Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.62 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.52 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | RAF1 | P04049 | 3/20 | 0.50 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5109724 | 0.94 | TRPM8 (0.72) | TRPM8MTNR1AMTNR1BKDM4EALDH1A1 | |
| SCHEMBL14078335 | 0.90 | TRPM8 (0.57) | TRPM8MTNR1AMTNR1BKDM4EALDH1A1 | |
| SCHEMBL5108268 | 0.90 | TRPM8 (0.57) | TRPM8MTNR1AMTNR1BKDM4EALDH1A1 | |
| SCHEMBL14078338 | 0.89 | TRPM8 (0.69) | TRPM8MTNR1AMTNR1BKDM4EALDH1A1 | |
| SCHEMBL5110016 | 0.88 | MTNR1A (0.58) | TRPM8MTNR1AMTNR1BKDM4ECYP1A2 | |
| Hydrochloric Acid SCHEMBL5114422 | 0.88 | TRPM8 (0.68) | TRPM8MTNR1AMTNR1BKDM4EALDH1A1 | |
| SCHEMBL5113509 | 0.86 | TRPM8 (0.60) | TRPM8MTNR1AMTNR1BKDM4EALDH1A1 | |
| SCHEMBL5184728 | 0.85 | TRPM8 (0.67) | TRPM8MTNR1AMTNR1BKDM4EALDH1A1 | |
| SCHEMBL5121399 | 0.84 | TRPM8 (0.54) | TRPM8MTNR1AMTNR1BKDM4ECYP1A2 | |
| SCHEMBL5110881 | 0.84 | TRPM8 (0.79) | TRPM8MTNR1AMTNR1BKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080214654-A1 | Substituted Benzyloxy-Phenylmethylamide Derivatives | BAYER HEALTHCARE AG (DE) | 2008-09-04 | — | — | US | disclosed |
| EP-1802600-A1 | SUBSTITUTED 4-BENZYLOXY-PHENYLMETHYLAMIDE DERIVATIVES AS COLD MENTHOL RECEPTOR-1 (CMR-1) ANTAGONITS FOR THE TREATMENT OF UROLOGICAL DISORDERS | Bayer HealthCare AG (DE) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006040136-A1 | SUBSTITUTED 4-BENZYLOXY-PHENYLMETHYLAMIDE DERIVATIVES AS COLD MENTHOL RECEPTOR-1 (CMR-1) ANTAGONISTS FOR THE TREATMENT OF UROLOGICAL DISORDER | BAYER HEALTHCARE AG (DE) | 2006-04-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214654-A1 | Substituted Benzyloxy-Phenylmethylamide Derivatives | OPRL1, ADRA1A, CNR1 | TRPM8 124/4885MTNR1A 132/4885MTNR1B 178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.