Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SCN10A | Q9Y5Y9 | 6/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.39 |
| ▸ | MLKL | Q8NB16 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL580331 | 0.83 | TAAR1 (0.46) | TAAR1ALDH1A1SCN10ACYP1A2KDM4E | |
| SCHEMBL12727236 | 0.83 | CYP1A2 (0.50) | TAAR1ALDH1A1HPGDUSP2HTT | |
| SCHEMBL4573758 | 0.82 | CYP1A2 (0.53) | TAAR1ALDH1A1HPGDUSP2HTT | |
| SCHEMBL15172642 | 0.81 | SCN10A (0.64) | TAAR1SCN10AS1PR4S1PR1S1PR5 | |
| SCHEMBL17910400 | 0.79 | KMT2A (0.43) | TAAR1ALDH1A1HPGDUSP2HTT | |
| SCHEMBL25160354 | 0.79 | CYP1A2 (0.54) | ALDH1A1HPGDUSP2HTTSCN10A | |
| SCHEMBL10640557 | 0.79 | TAAR1 (0.71) | TAAR1ALDH1A1SCN10ACYP1A2KMT2A | |
| SCHEMBL15172653 | 0.79 | SCN10A (0.48) | TAAR1ALDH1A1SCN10AS1PR4S1PR1 | |
| Hydrochloric Acid SCHEMBL17910969 | 0.78 | KMT2A (0.42) | TAAR1ALDH1A1HPGDUSP2HTT | |
| SCHEMBL2757079 | 0.78 | KDM4E (0.59) | ALDH1A1HPGDUSP2HTTSCN10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080207683-A1 | BIARYL-SUBSTITUTED TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S | SUNESIS PHARMACEUTICALS, INC. | 2008-08-28 | — | — | US | claimed |
| US-20080207683-A1 | BIARYL-SUBSTITUTED TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S | SUNESIS PHARMACEUTICALS, INC. | 2008-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207683-A1 | BIARYL-SUBSTITUTED TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S | CTSS, CTSK, CTSZ | TAAR1 3733/4885ALDH1A1 4560/4885HPGD 2447/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.