Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 9/20 | 0.56 |
| ▸ | CCNK | O75909 | 2/20 | 0.54 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.54 |
| ▸ | IKBKB | O14920 | 5/20 | 0.48 |
| ▸ | CHUK | O15111 | 5/20 | 0.48 |
| ▸ | NUDT1 | P36639 | 3/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | PAK4 | O96013 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | PRKACA | P17612 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | LTK | P29376 | 1/20 | 0.46 |
| ▸ | GRK5 | P34947 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5105198 | 0.81 | PRKCI (0.52) | PRKCICCNKCDK12IKBKBCHUK | |
| SCHEMBL5120405 | 0.78 | CCNK (0.62) | PRKCICCNKCDK12IKBKBCHUK | |
| SCHEMBL5104180 | 0.72 | PIK3CA (0.48) | JAK2MAP4K4CDK8CLK2CDK7 | |
| SCHEMBL2239087 | 0.71 | IKBKB (0.61) | PRKCICCNKCDK12IKBKBCHUK | |
| SCHEMBL4792517 | 0.71 | IKBKB (0.70) | PRKCICCNKCDK12IKBKBCHUK | |
| SCHEMBL5110510 | 0.70 | NLRP3 (0.44) | JAK2 | |
| SCHEMBL856991 | 0.70 | PRKCI (0.57) | PRKCICCNKCDK12IKBKBCHUK | |
| SCHEMBL1838406 | 0.69 | NUDT1 (0.67) | PRKCICCNKCDK12IKBKBCHUK | |
| SCHEMBL1718599 | 0.69 | NUDT1 (0.69) | PRKCICCNKCDK12IKBKBCHUK | |
| SCHEMBL20849787 | 0.69 | CCNK (0.56) | PRKCICCNKCDK12IKBKBCHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080234276-A1 | Heterocyclic Triazines as Hypoxic Selective Protein Kinase Inhibitors | SENTINEL ONCOLOGY LIMITED (UK) | 2008-09-25 | — | — | US | claimed |
| EP-1846392-A2 | HETEROCYCLIC TRIAZINES AS HYPOXIC SELECTIVE PROTEIN KINASE INHIBITORS | Sentinel Oncology Limited (GB) | 2007-10-24 | — | — | EP | claimed |
| WO-2006131835-A2 | HETEROCYCLIC TRIAZINES AS HYPOXIC SELECTIVE PROTEIN KINASE INHIBITORS | SENTINEL ONCOLOGY LIMITED (GB) | 2006-12-14 | — | — | WO | claimed |
| US-20080234276-A1 | Heterocyclic Triazines as Hypoxic Selective Protein Kinase Inhibitors | SENTINEL ONCOLOGY LIMITED (UK) | 2008-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234276-A1 | Heterocyclic Triazines as Hypoxic Selective Protein Kinase Inhibitors | HIF1AN, HIF1A, CDK2 | PRKCI 216/4885CCNK 46/4885CDK12 23/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.