Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.37 |
| ▸ | CACNB1 | Q02641 | 2/20 | 0.37 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PHGDH | O43175 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4194097 | 0.86 | DPP4 (0.38) | CYP1A2TDP1HTR1APOLBNPSR1 | |
| SCHEMBL12583610 | 0.79 | HTR1A (0.47) | CYP1A2TDP1HTR1APOLBNPSR1 | |
| SCHEMBL12583677 | 0.79 | HTR1A (0.47) | CYP1A2TDP1HTR1APOLBNPSR1 | |
| SCHEMBL13383340 | 0.79 | HTR1A (0.47) | CYP1A2TDP1HTR1APOLBNPSR1 | |
| SCHEMBL4186778 | 0.78 | L3MBTL1 (0.48) | POLBL3MBTL1KMT2ASMN1; SMN2 | |
| SCHEMBL5113390 | 0.78 | GABRR1 (0.42) | CYP1A2TDP1HTR1APOLBNPSR1 | |
| SCHEMBL4184867 | 0.77 | HTR1A (0.40) | CYP1A2TDP1HTR1APOLBNPSR1 | |
| SCHEMBL16654196 | 0.77 | HTR1A (0.46) | CYP1A2TDP1HTR1APOLBNPSR1 | |
| SCHEMBL22248833 | 0.77 | HTR1A (0.46) | CYP1A2TDP1HTR1APOLBNPSR1 | |
| SCHEMBL2625513 | 0.76 | POLB (0.61) | CYP1A2TDP1HTR1APOLBNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080044881-A1 | Advanced Indolinone Based Protein Kinase Inhibitors | SCRIPPS RESEARCH INSTITUTE, THE | 2008-02-21 | — | — | US | disclosed |
| CN-1905869-A | Indolinone based protein kinase inhibitors | SCRIPPS RESEARCH INST (US) | 2007-01-31 | — | — | CN | disclosed |
| US-20060287381-A1 | Enhanced indolinone based protein kinase inhibitors | THE SCRIPPS RESEARCH INSTITUTE (US) | 2006-12-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060287381-A1 | Enhanced indolinone based protein kinase inhibitors | PHKG1, PHKG2, PRKCH | CYP1A2 3080/4885TDP1 1025/4885HTR1A 716/4885 |
| US-20080044881-A1 | Advanced Indolinone Based Protein Kinase Inhibitors | PHKG1, PHKG2, HIPK1 | CYP1A2 3918/4885TDP1 651/4885HTR1A 1266/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.