Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | NQO1 | P15559 | 4/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | PRNP | P04156 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | VKORC1 | Q9BQB6 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | PCSK7 | Q16549 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5115619 | 0.85 | NQO1 (0.38) | ALDH1A1NQO1ADORA3KDM4ERXFP1 | |
| SCHEMBL5125455 | 0.84 | TP53 (0.38) | ALDH1A1NQO1KDM4ERXFP1KMT2A | |
| SCHEMBL5119698 | 0.84 | PRNP (0.40) | ALDH1A1NQO1KDM4EPRNPRXFP1 | |
| SCHEMBL5115962 | 0.84 | NQO1 (0.52) | ALDH1A1NQO1ADORA3KDM4ERXFP1 | |
| SCHEMBL5111977 | 0.83 | NQO1 (0.48) | ALDH1A1NQO1KDM4ERXFP1KMT2A | |
| SCHEMBL5125494 | 0.82 | NQO1 (0.47) | ALDH1A1NQO1PRNPRXFP1KMT2A | |
| SCHEMBL5115168 | 0.82 | NQO1 (0.47) | ALDH1A1NQO1KDM4ERXFP1TP53 | |
| SCHEMBL5118330 | 0.82 | CA12 (0.46) | ALDH1A1NQO1PRNPRXFP1VKORC1 | |
| SCHEMBL5126458 | 0.81 | ALDH1A1 (0.40) | ALDH1A1NQO1ADORA3KDM4EKMT2A | |
| SCHEMBL5114980 | 0.81 | NQO1 (0.52) | ALDH1A1NQO1ADORA3KDM4EVKORC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7384975-B2 | Substituted furochromenes, preparation thereof and their antiinflammatory action | GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (HR) | 2008-06-10 | — | — | US | disclosed |
| US-20060148889-A1 | Substituted furochromenes, preparation thereof and their antiinflammatory action | PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2006-07-06 | — | — | US | disclosed |
| EP-1648902-A1 | SUBSTITUTED FUROCHROMENES, PREPARATION THEREOF AND THEIR ANTIINFLAMMATORY ACTION | PLIVA-ISTRAZIVACKI INSTITUT d.o.o. (HR) | 2006-04-26 | — | — | EP | disclosed |
| US-20050075388-A1 | Products of condensations of hydroxycoumarin derivatives with aromatic and aliphatic dialdehydes, their preparation and antiviral action thereof | PLIVA-ISTRAZIVACKI INSTITUTE D.O.O. (HR) | 2005-04-07 | — | — | US | disclosed |
| WO-2005010007-A1 | SUBSTITUTED FUROCHROMENES, PREPARATION THEREOF AND THEIR ANTIINFLAMMATORY ACTION | PLIVA- ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2005-02-03 | — | — | WO | disclosed |
| EP-1448543-A1 | PRODUCTS OF CONDENSATIONS OF HYDROXYCOUMARIN DERIVATIVES WITH AROMATIC AND ALIPHATIC DIALDEHYDES, THEIR PREPARATION AND ANTIVIRAL ACTION THEREOF | PLIVA-ISTRAZIVACKI INSTITUT d.o.o. (HR) | 2004-08-25 | — | — | EP | disclosed |
| WO-2003029237-A1 | PRODUCTS OF CONDENSATIONS OF HYDROXYCOUMARIN DERIVATIVES WITH AROMATIC AND ALIPHATIC DIALDEHYDES, THEIR PREPARATION AND ANTIVIRAL ACTION THEREOF | PLIVA, FARMACEUTSKA INDUSTRIJA, DIONICKO DRUSTVO (HR) | 2003-04-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050075388-A1 | Products of condensations of hydroxycoumarin derivatives with aromatic and aliphatic dialdehydes, their preparation and antiviral action thereof | MAVS, EIF2AK2, DDX17 | ALDH1A1 633/4885NQO1 199/4885ADORA3 2950/4885 |
| US-20060148889-A1 | Substituted furochromenes, preparation thereof and their antiinflammatory action | CYP11B2, CYP11B1, LTC4S | ALDH1A1 486/4885NQO1 60/4885ADORA3 1155/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.