SCHEMBL5114780

SCHEMBL5114780

O=C(OC12CC3CC(CC(C3)C1)C2)c1c2ccccc2cc2ccccc12

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.45
HPGD P15428 3/20 0.45
MEN1 O00255 2/20 0.45
ALDH1A1 P00352 2/20 0.45
KMT2A Q03164 2/20 0.45
CYP1A2 P05177 1/20 0.45
GLA P06280 1/20 0.45
CYP2C19 P33261 1/20 0.45
HSD17B10 Q99714 1/20 0.45
CYP19A1 P11511 4/20 0.40
CYP17A1 P05093 3/20 0.40
HSP90AA1 P07900 1/20 0.39
CKS1B P61024 1/20 0.39
SKP1 P63208 1/20 0.39
SKP2 Q13309 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
CNR2 P34972 1/20 0.36
MAPT P10636 1/20 0.36
CASR P41180 1/20 0.36
FAAH O00519 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14295761 0.77 ALDH1A1 (0.40) KDM4EHPGDMEN1ALDH1A1KMT2A
SCHEMBL22822742 0.77 HSP90AA1 (0.46) KDM4EHPGDMEN1ALDH1A1KMT2A
SCHEMBL8134445 0.76 CYP19A1 (0.46) KDM4EHPGDMEN1ALDH1A1KMT2A
SCHEMBL11575818 0.74 FAAH (0.51) KDM4EALDH1A1CYP19A1CYP17A1HSP90AA1
SCHEMBL8129733 0.73 HSP90AA1 (0.48) HPGDMEN1ALDH1A1KMT2ACYP1A2
SCHEMBL2892925 0.72 ALDH1A1 (0.38) KDM4EHPGDMEN1ALDH1A1KMT2A
SCHEMBL14277056 0.72 CYP19A1 (0.39) KDM4EHPGDALDH1A1KMT2ACYP19A1
SCHEMBL6940992 0.71 ALDH1A1 (0.63) KDM4EHPGDMEN1ALDH1A1KMT2A
SCHEMBL31240530 0.71 ALDH1A1 (0.63) KDM4EHPGDMEN1ALDH1A1KMT2A
SCHEMBL24804782 0.71 P2RX7 (0.42) KDM4EMEN1ALDH1A1KMT2ACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7326510-B2 Polycarbocyclic derivatives for modification of resist, optical and etch resistance properties GOGOLIDES EVANGELOS 2008-02-05 US disclosed
EP-1444550-B1 POLYCARBOCYCLIC DERIVATIVES FOR MODIFICATION OF RESIST, OPTICAL AND ETCH RESISTANCE PROPERTIES NCSR DEMOKRITOS (GR) 2005-09-21 EP disclosed
US-20050026068-A1 Polycarbocyclic derivatives for modification of resist, optical and etch resistance properties GOGOLIDES EVANGELOS (GR) 2005-02-03 US disclosed
EP-1444550-A2 POLYCARBOCYCLIC DERIVATIVES FOR MODIFICATION OF RESIST, OPTICAL AND ETCH RESISTANCE PROPERTIES NCSR DEMOKRITOS (GR) 2004-08-11 EP disclosed
WO-2003038523-A2 POLYCARBOCYCLIC DERIVATIVES FOR MODIFICATION OF RESIST, OPTICAL AND ETCH RESISTANCE PROPERTIES NCSR DEMOKRITOS (GR) 2003-05-08 WO disclosed