Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 4/20 | 0.46 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.45 |
| ▸ | F11 | P03951 | 1/20 | 0.44 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.44 |
| ▸ | CDC7 | O00311 | 6/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.43 |
| ▸ | AKT1 | P31749 | 4/20 | 0.43 |
| ▸ | CDK2 | P24941 | 5/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.42 |
| ▸ | PIM1 | P11309 | 3/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.42 |
| ▸ | PRKACA | P17612 | 3/20 | 0.42 |
| ▸ | FLT3 | P36888 | 3/20 | 0.42 |
| ▸ | GSK3B | P49841 | 3/20 | 0.42 |
| ▸ | JAK3 | P52333 | 3/20 | 0.42 |
| ▸ | HIPK2 | Q9H2X6 | 3/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.42 |
| ▸ | AKT3 | Q9Y243 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL505088 | 0.80 | KLKB1 (0.49) | F11KLKB1 | |
| SCHEMBL393271 | 0.78 | F11 (0.65) | F11KLKB1 | |
| SCHEMBL5115939 | 0.73 | CAMKK2 (0.46) | ROCK1CAMKK2CDC7ADORA2ADBF4 | |
| SCHEMBL5122984 | 0.73 | CAMKK2 (0.51) | ROCK1CAMKK2CDC7ADORA2ADBF4 | |
| SCHEMBL14311088 | 0.71 | CDC7 (0.48) | ROCK1CAMKK2CDC7ADORA2ADBF4 | |
| SCHEMBL27724873 | 0.69 | CYP1A2 (0.47) | — | |
| SCHEMBL391686 | 0.69 | CYP1A2 (0.47) | — | |
| SCHEMBL5122988 | 0.69 | CAMKK2 (0.51) | ROCK1CAMKK2CDC7DBF4CDK2 | |
| SCHEMBL4789988 | 0.67 | PDPK1 (0.49) | ROCK1CAMKK2CDC7CDK2ROCK2 | |
| SCHEMBL392214 | 0.67 | CYP1A2 (0.45) | F11KLKB1ADORA2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080021217-A1 | HETEROCYCLIC INHIBITORS OF RHO KINASE | Borchardt, Allen (US) | 2008-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080021217-A1 | HETEROCYCLIC INHIBITORS OF RHO KINASE | ROCK1, ROCK2, RHOA | ROCK1 1/4885CAMKK2 87/4885F11 2475/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.