Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.46 |
| ▸ | CDC7 | O00311 | 7/20 | 0.46 |
| ▸ | CDK2 | P24941 | 5/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.46 |
| ▸ | PIM1 | P11309 | 3/20 | 0.46 |
| ▸ | PRKACA | P17612 | 3/20 | 0.46 |
| ▸ | GSK3B | P49841 | 3/20 | 0.46 |
| ▸ | HIPK2 | Q9H2X6 | 3/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.46 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.43 |
| ▸ | PLK4 | O00444 | 2/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | CSF1R | P07333 | 2/20 | 0.43 |
| ▸ | RET | P07949 | 2/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.43 |
| ▸ | TYK2 | P29597 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5122984 | 0.79 | CAMKK2 (0.51) | CAMKK2CDC7CDK2ROCK2PIM1 | |
| SCHEMBL14311088 | 0.78 | CDC7 (0.48) | CAMKK2CDC7CDK2ROCK2PIM1 | |
| SCHEMBL505089 | 0.78 | SMN1; SMN2 (0.47) | ROCK2GRK2 | |
| SCHEMBL4789988 | 0.76 | PDPK1 (0.49) | CAMKK2CDC7CDK2ROCK2PIM1 | |
| SCHEMBL5122988 | 0.75 | CAMKK2 (0.51) | CAMKK2CDC7CDK2ROCK2PIM1 | |
| SCHEMBL14289641 | 0.74 | JAK3 (0.47) | CAMKK2CDC7CDK2ROCK2PIM1 | |
| SCHEMBL5115936 | 0.73 | ROCK1 (0.46) | CAMKK2CDC7CDK2ROCK2PIM1 | |
| SCHEMBL5117005 | 0.71 | TSHR (0.45) | CAMKK2ROCK2PIM1PRKACAGSK3B | |
| SCHEMBL14289640 | 0.69 | ADORA2A (0.44) | CAMKK2CDC7ROCK2ROCK1DBF4 | |
| SCHEMBL5122742 | 0.69 | ROCK2 (0.45) | CAMKK2CDC7CDK2ROCK2PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080021217-A1 | HETEROCYCLIC INHIBITORS OF RHO KINASE | Borchardt, Allen (US) | 2008-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080021217-A1 | HETEROCYCLIC INHIBITORS OF RHO KINASE | ROCK1, ROCK2, RHOA | CAMKK2 87/4885CDC7 157/4885CDK2 159/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.