Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 1/20 | 0.60 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.60 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.60 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.60 |
| ▸ | MAOA | P21397 | 3/20 | 0.59 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.56 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5111868 | 0.84 | MAOA (0.81) | ABCC9ABCC8KCNJ11KCNJ8MAOA | |
| SCHEMBL5110628 | 0.82 | ABCC9 (0.51) | ABCC9ABCC8KCNJ11KCNJ8MAOA | |
| SCHEMBL6339286 | 0.82 | ABCC9 (0.60) | ABCC9ABCC8KCNJ11KCNJ8MAOA | |
| SCHEMBL5113480 | 0.80 | ABCC9 (0.51) | ABCC9ABCC8KCNJ11KCNJ8MAOA | |
| SCHEMBL13391074 | 0.77 | ALDH1A1 (0.71) | MAOAPDK2ALDH1A1KDM4EGLA | |
| SCHEMBL6416133 | 0.76 | ABCC9 (0.57) | ABCC9ABCC8KCNJ11KCNJ8MAOA | |
| SCHEMBL5110259 | 0.76 | ABCC9 (0.57) | ABCC9ABCC8KCNJ11KCNJ8MAOA | |
| SCHEMBL5113896 | 0.75 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8MAOA | |
| SCHEMBL5113168 | 0.75 | ABCC9 (0.48) | ABCC9ABCC8KCNJ11KCNJ8MAOA | |
| SCHEMBL6339283 | 0.71 | NPY5R (0.57) | ABCC9ABCC8KCNJ11KCNJ8MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7332492-B2 | Amino substituted dibenzothiophene derivatives for the treatment of disorders mediated by NP Y5 receptor | ASTRAZENECA AB (SE) | 2008-02-19 | — | — | US | disclosed |
| US-20050209233-A1 | Amino substituted dibenzothiophene derivatives for the treatment of disorders mediated by NP Y5 receptor | ASTRAZENECA AB (SE) | 2005-09-22 | — | — | US | disclosed |
| US-20030225097-A1 | Amino substituted dibenzothiophene derivatives for the treatment of disorders mediated by np y5 receptor | ASTRAZENECA AB (SE) | 2003-12-04 | — | — | US | disclosed |
| EP-1278739-A1 | AMINO SUBSTITUTED DIBENZOTHIOPHENE DERIVATIVES FOR THE TREATMENT OF DISORDERS MEDIATED BY THE NP Y5 RECEPTOR | AstraZeneca AB (SE) | 2003-01-29 | — | — | EP | disclosed |
| WO-2001085714-A1 | AMINO SUBSTITUTED DIBENZOTHIOPHENE DERIVATIVES FOR THE TREATMENT OF DISORDERS MEDIATED BY THE NP Y5 RECEPTOR | ASTRAZENECA AB (SE) | 2001-11-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050209233-A1 | Amino substituted dibenzothiophene derivatives for the treatment of disorders mediated by NP Y5 receptor | NPY5R, NPY1R, NPY2R | ABCC9 3402/4885ABCC8 3798/4885KCNJ11 3207/4885 |
| US-20030225097-A1 | Amino substituted dibenzothiophene derivatives for the treatment of disorders mediated by np y5 receptor | NPY5R, NPY1R, NPY2R | ABCC9 4182/4885ABCC8 4453/4885KCNJ11 3483/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.