Sugi Predict

Sugi Predict / Compounds / SCHEMBL5118825

SCHEMBL5118825

SCHEMBL5118825

Cc1cc2oc(=O)c(-c3cc4c(=O)oc5cc(C)c(C)cc5c4o3)c(O)c2cc1C

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NQO1 P15559 8/20 0.52
▸ ESR1 P03372 3/20 0.41
▸ ESR2 Q92731 3/20 0.41
▸ ERAP1 Q9NZ08 1/20 0.38
▸ MAOB P27338 2/20 0.38
▸ HSD17B3 P37058 1/20 0.36
▸ NOX4 Q9NPH5 1/20 0.35
▸ NPC1 O15118 1/20 0.35
▸ HDAC3 O15379 1/20 0.35
▸ NUAK1 O60285 1/20 0.35
▸ IGF1R P08069 1/20 0.35
▸ MET P08581 1/20 0.35
▸ PIM1 P11309 1/20 0.35
▸ SRC P12931 1/20 0.35
▸ AXL P30530 1/20 0.35
▸ AKT1 P31749 1/20 0.35
▸ KDR P35968 1/20 0.35
▸ NEK2 P51955 1/20 0.35
▸ PLK1 P53350 1/20 0.35
▸ HDAC4 P56524 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5119551 0.89 NQO1 (0.42) NQO1ESR1ESR2ERAP1MAOB
SCHEMBL5125176 0.83 MAOB (0.56) NQO1MAOBKDM4EMEN1CYP3A4
SCHEMBL5114480 0.81 MAOA (0.40) NQO1ERAP1MAOBNOX4KDM4E
SCHEMBL5115329 0.81 MAOB (0.44) NQO1ESR1ESR2ERAP1MAOB
SCHEMBL5118497 0.80 ESR2 (0.49) ESR1ESR2ERAP1MAOBNOX4
SCHEMBL5112059 0.78 NQO1 (0.55) NQO1MAOBMEN1KMT2A
SCHEMBL5111547 0.78 MAOA (0.59) NQO1MAOBKDM4EMEN1MAPT
SCHEMBL5114313 0.78 CA12 (0.52) NQO1ESR1ESR2MAOBPIM1
SCHEMBL5112054 0.78 CSNK2A2 (0.41) NQO1MAOBKDM4ECSNK2A2CSNK2B
SCHEMBL5115686 0.78 NQO1 (0.57) NQO1ESR2MAOBNPC1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7384975-B2 Substituted furochromenes, preparation thereof and their antiinflammatory action GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (HR) 2008-06-10 — — US claimed
US-20060148889-A1 Substituted furochromenes, preparation thereof and their antiinflammatory action PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) 2006-07-06 — — US claimed
US-7384975-B2 Substituted furochromenes, preparation thereof and their antiinflammatory action GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (HR) 2008-06-10 — — US disclosed
US-7384975-B2 Substituted furochromenes, preparation thereof and their antiinflammatory action GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (HR) 2008-06-10 — — US disclosed
US-7384975-B2 Substituted furochromenes, preparation thereof and their antiinflammatory action GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (HR) 2008-06-10 — — US disclosed
US-20060148889-A1 Substituted furochromenes, preparation thereof and their antiinflammatory action PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) 2006-07-06 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060148889-A1 Substituted furochromenes, preparation thereof and their antiinflammatory action CYP11B2, CYP11B1, LTC4S NQO1 60/4885ESR1 1942/4885ESR2 962/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.