Sugi Predict

Sugi Predict / Compounds / SCHEMBL5114480

SCHEMBL5114480

SCHEMBL5114480

O=c1oc2cc3ccccc3cc2c(O)c1-c1cc2c(=O)oc3cc4ccccc4cc3c2o1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAOA P21397 1/20 0.40
▸ NQO1 P15559 5/20 0.39
▸ ERAP1 Q9NZ08 1/20 0.39
▸ NPSR1 Q6W5P4 2/20 0.39
▸ RXFP1 Q9HBX9 2/20 0.39
▸ HPGD P15428 2/20 0.39
▸ TYR P14679 1/20 0.39
▸ DAO P14920 1/20 0.39
▸ AKR1B1 P15121 1/20 0.39
▸ MAOB P27338 2/20 0.39
▸ LMNA P02545 1/20 0.37
▸ PPARG P37231 1/20 0.37
▸ NCOA2 Q15596 1/20 0.37
▸ NCOR2 Q9Y618 1/20 0.37
▸ NOX4 Q9NPH5 1/20 0.36
▸ CYP3A4 P08684 2/20 0.36
▸ PSMD14 O00487 1/20 0.36
▸ CYP1A1 P04798 1/20 0.36
▸ CYP1A2 P05177 1/20 0.36
▸ CSNK2A2 P19784 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5111292 0.82 KDM4E (0.50) MAOANQO1HPGDMAOBLMNA
SCHEMBL5118497 0.81 ESR2 (0.49) MAOAERAP1NPSR1RXFP1HPGD
SCHEMBL5118825 0.81 NQO1 (0.52) NQO1ERAP1MAOBNOX4CYP3A4
SCHEMBL5112059 0.78 NQO1 (0.55) MAOANQO1MAOBLMNAMEN1
SCHEMBL5114313 0.78 CA12 (0.52) MAOANQO1MAOBCSNK2A2CSNK2B
SCHEMBL5125176 0.78 MAOB (0.56) MAOANQO1HPGDMAOBCYP3A4
SCHEMBL5111547 0.78 MAOA (0.59) MAOANQO1HPGDMAOBKDM4E
SCHEMBL5115686 0.78 NQO1 (0.57) MAOANQO1RXFP1HPGDMAOB
SCHEMBL5111826 0.78 NOX4 (0.57) MAOANQO1ERAP1NPSR1RXFP1
SCHEMBL5111602 0.76 TDP1 (0.47) HPGDMAOBCYP3A4PSMD14CYP1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7384975-B2 Substituted furochromenes, preparation thereof and their antiinflammatory action GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (HR) 2008-06-10 — — US claimed
US-20060148889-A1 Substituted furochromenes, preparation thereof and their antiinflammatory action PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) 2006-07-06 — — US claimed
US-7384975-B2 Substituted furochromenes, preparation thereof and their antiinflammatory action GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (HR) 2008-06-10 — — US disclosed
US-7384975-B2 Substituted furochromenes, preparation thereof and their antiinflammatory action GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (HR) 2008-06-10 — — US disclosed
US-7384975-B2 Substituted furochromenes, preparation thereof and their antiinflammatory action GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (HR) 2008-06-10 — — US disclosed
US-20060148889-A1 Substituted furochromenes, preparation thereof and their antiinflammatory action PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) 2006-07-06 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060148889-A1 Substituted furochromenes, preparation thereof and their antiinflammatory action CYP11B2, CYP11B1, LTC4S MAOA 327/4885NQO1 60/4885ERAP1 1192/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.