Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 16/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 15/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 15/20 | 0.53 |
| ▸ | LMNA | P02545 | 7/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 14/20 | 0.49 |
| ▸ | USP2 | O75604 | 12/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | HBB | P68871 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5106687 | 0.83 | LMNA (0.50) | LMNAALDH1A1MEN1KMT2ARECQL | |
| SCHEMBL5105792 | 0.81 | CYP1A2 (0.50) | CYP1A2CYP2C9CYP2C19LMNACYP3A4 | |
| SCHEMBL4314434 | 0.80 | PDE4A (0.52) | CYP1A2CYP2C9CYP2C19LMNACYP3A4 | |
| SCHEMBL5111971 | 0.79 | PDE4A (0.50) | CYP1A2CYP2C9CYP2C19LMNAALDH1A1 | |
| SCHEMBL5108726 | 0.78 | MEN1 (0.46) | LMNAUSP2ALDH1A1MEN1KMT2A | |
| SCHEMBL5106062 | 0.77 | PDE4A (0.51) | CYP1A2CYP2C9CYP2C19LMNAALDH1A1 | |
| SCHEMBL4098315 | 0.77 | LMNA (0.48) | LMNAUSP2ALDH1A1MEN1KMT2A | |
| SCHEMBL5118726 | 0.77 | PDE4A (0.50) | LMNAMEN1KMT2APDE4APDE4B | |
| SCHEMBL4091105 | 0.75 | PDE4A (0.51) | LMNAALDH1A1MEN1KMT2ARECQL | |
| SCHEMBL5647619 | 0.73 | TDP1 (0.55) | CYP2C19LMNACYP3A4ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7332498-B2 | Modulation of KSP kinesin activity with heterocyclic-fused pyrimidinone derivatives | CYTOKINETICS, INC. (US) | 2008-02-19 | — | — | US | disclosed |
| US-20060111374-A1 | Compounds, compositions, and methods | CYTOKINETICS, INC. | 2006-05-25 | — | — | US | disclosed |
| US-7038048-B2 | 3H-pyridopyrimidin-4-one compounds, compositions, and methods of their use | CYTOKINETICS, INC. (US) | 2006-05-02 | — | — | US | disclosed |
| US-20040116438-A1 | Compounds, compositions, and methods | CYTOKINETICS, INCORPORATED | 2004-06-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060111374-A1 | Compounds, compositions, and methods | ALPP, MKI67, PCNA | CYP1A2 4057/4885CYP2C9 4768/4885CYP2C19 4688/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.