Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5119733 | 0.93 | KMT2A (0.46) | ALDH1A1L3MBTL1GAAKDM4ENAMPT | |
| SCHEMBL5121677 | 0.91 | LMNA (0.41) | ALDH1A1HTTL3MBTL1GAAGPR119 | |
| SCHEMBL5111528 | 0.91 | GAA (0.42) | ALDH1A1HTTL3MBTL1MAPK1GAA | |
| SCHEMBL5119611 | 0.91 | ALDH1A1 (0.42) | ALDH1A1L3MBTL1MAPK1GAANAMPT | |
| SCHEMBL5125515 | 0.90 | L3MBTL1 (0.43) | ALDH1A1HTTL3MBTL1GAAKDM4E | |
| SCHEMBL5120842 | 0.90 | ALDH1A1 (0.43) | ALDH1A1L3MBTL1GAAKDM4ENAMPT | |
| SCHEMBL5125610 | 0.88 | ALDH1A1 (0.47) | ALDH1A1HTTL3MBTL1MAPK1KDM4E | |
| SCHEMBL1457238 | 0.88 | ALDH1A1 (0.41) | ALDH1A1HTTL3MBTL1MAPK1GAA | |
| SCHEMBL5118862 | 0.87 | SMN1; SMN2 (0.47) | ALDH1A1HTTMAPK1GAANAMPT | |
| SCHEMBL5126616 | 0.85 | ALDH1A1 (0.54) | ALDH1A1HTTMAPK1GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080214807-A1 | Substituted Spiro Compounds and their Use for Producing Drugs | GRUENENTHAL GMBH (DE) | 2008-09-04 | — | — | US | claimed |
| US-20080214807-A1 | Substituted Spiro Compounds and their Use for Producing Drugs | GRUENENTHAL GMBH (DE) | 2008-09-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214807-A1 | Substituted Spiro Compounds and their Use for Producing Drugs | REN, PKD1, NR3C2 | ALDH1A1 281/4885HTT 1428/4885L3MBTL1 4872/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.