Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.71 |
| ▸ | NPC1 | O15118 | 6/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.71 |
| ▸ | RAB9A | P51151 | 6/20 | 0.71 |
| ▸ | TSHR | P16473 | 2/20 | 0.71 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.71 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.71 |
| ▸ | RELA | Q04206 | 1/20 | 0.71 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | KDM6B | O15054 | 1/20 | 0.52 |
| ▸ | KDM4A | O75164 | 1/20 | 0.52 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1991539 | 0.83 | SMN1; SMN2 (1.00) | SMN1; SMN2NPC1ALDH1A1RAB9ATSHR | |
| SCHEMBL5658074 | 0.81 | ALDH1A1 (0.61) | SMN1; SMN2NPC1ALDH1A1RAB9ATSHR | |
| SCHEMBL1158167 | 0.79 | SMN1; SMN2 (0.52) | SMN1; SMN2NPC1ALDH1A1RAB9ATSHR | |
| SCHEMBL1351680 | 0.78 | ALDH1A1 (0.55) | SMN1; SMN2NPC1ALDH1A1RAB9ATSHR | |
| SCHEMBL1352765 | 0.77 | SMN1; SMN2 (0.54) | SMN1; SMN2NPC1ALDH1A1RAB9ATSHR | |
| SCHEMBL5658070 | 0.77 | SMN1; SMN2 (0.46) | SMN1; SMN2NPC1ALDH1A1RAB9ATSHR | |
| SCHEMBL14587561 | 0.74 | SMN1; SMN2 (0.43) | SMN1; SMN2NPC1ALDH1A1RAB9ATSHR | |
| SCHEMBL5658477 | 0.74 | ALDH1A1 (0.57) | SMN1; SMN2NPC1ALDH1A1RAB9ATSHR | |
| SCHEMBL811481 | 0.74 | ALDH1A1 (0.78) | SMN1; SMN2NPC1ALDH1A1RAB9ATSHR | |
| SCHEMBL27718774 | 0.74 | SMN1; SMN2 (0.57) | SMN1; SMN2NPC1ALDH1A1RAB9ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449581-B2 | 6-Substituted pyrido-pyrimidines | POCHE PALO ALTO LLC (US) | 2008-11-11 | — | — | US | disclosed |
| US-7285559-B2 | Imidazo-substituted compounds as p38 kinase inhibitors | ROCHE PALO ALTO LLC (US) | 2007-10-23 | — | — | US | disclosed |
| US-7285561-B2 | Imidazo-substituted compounds as p38 kinase inhibitors | ROCHE PALO ALTO LLC (US) | 2007-10-23 | — | — | US | disclosed |
| US-20070135458-A1 | 6-Substituted pyrido-pyrimidines | CHEN JIAN J | 2007-06-14 | — | — | US | disclosed |
| EP-1228070-B1 | HETEROALKYLAMINO-SUBSTITUTED BICYCLIC NITROGEN HETEROCYCLES AS INHIBITORS OF P38 PROTEIN KINASE | HOFFMANN LA ROCHE (CH) | 2007-02-07 | — | — | EP | disclosed |
| US-7169794-B2 | 6-substituted pyrido-pyrimidines | ROCHE PALO ALTO LLC (US) | 2007-01-30 | — | — | US | disclosed |
| US-20060252783-A1 | Imidazo-substituted compounds as p38 kinase inhibitors | GOLDSTEIN DAVID M | 2006-11-09 | — | — | US | disclosed |
| US-20060252784-A1 | Imidazo-substituted compounds as P38 kinase inhibitors | GOLDSTEIN DAVID M | 2006-11-09 | — | — | US | disclosed |
| US-7081462-B2 | Imidazo-substituted compounds as p38 kinase inhibitors | ROCHE PALO ALTO LLC (US) | 2006-07-25 | — | — | US | disclosed |
| EP-1361880-B1 | 6-SUBSTITUTED PYRIDO-PYRIMIDINES | HOFFMANN LA ROCHE (CH) | 2005-09-28 | — | — | EP | disclosed |
| US-20040116698-A1 | 6-Substituted pyrido-pyrimidines | CHEN JIAN JEFFREY (US) | 2004-06-17 | — | — | US | disclosed |
| US-6696566-B2 | SELECTIVE P38 KINASE INHIBITORS RELATIVE TO CYCLIN-DEPENDENT KINASES AND TYROSINE KINASES | SYNTEX (U.S.A.) LLC | 2004-02-24 | — | — | US | disclosed |
| US-20030232847-A1 | Imidazo-substituted compounds as p38 kinase inhibitors | ROCHE PALO ALTO LLC | 2003-12-18 | — | — | US | disclosed |
| EP-1361880-A2 | 6-SUBSTITUTED PYRIDO-PYRIMIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-11-19 | — | — | EP | disclosed |
| WO-2003082871-A1 | IMIDAZO FUSED COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-10-09 | — | — | WO | disclosed |
| US-20030171584-A1 | Treating p38 mediated disorders such as arthritis, Crohns disease, irritable bowel syndrome adult respiratory distress syndrome or chronic obstructive pulmonary disease. | SYNTEX (U.S.A.) LLC | 2003-09-11 | — | — | US | disclosed |
| US-6451804-B1 | Heteroalkylamino-substituted bicyclic nitrogen heterocycles | SYNTEX (U.S.A.) LLC | 2002-09-17 | — | — | US | disclosed |
| WO-2002064594-A2 | 6-SUBSTITUTED PYRIDO-PYRIMIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-08-22 | — | — | WO | disclosed |
| EP-1228070-A1 | HETEROALKYLAMINO-SUBSTITUTED BICYCLIC NITROGEN HETEROCYCLES AS INHIBITORS OF P38 PROTEIN KINASE | F. HOFFMANN-LA ROCHE AG (CH) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001029042-A1 | HETEROALKYLAMINO-SUBSTITUTED BICYCLIC NITROGEN HETEROCYCLES AS INHIBITORS OF P38 PROTEIN KINASE | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060252784-A1 | Imidazo-substituted compounds as P38 kinase inhibitors | MAPK1, MAP3K1, MAPK3 | SMN1; SMN2 2552/4885NPC1 1932/4885ALDH1A1 1207/4885 |
| US-20070135458-A1 | 6-Substituted pyrido-pyrimidines | P2RX6, P2RX1, P2RX7 | SMN1; SMN2 2069/4885NPC1 3852/4885ALDH1A1 1244/4885 |
| US-20060252783-A1 | Imidazo-substituted compounds as p38 kinase inhibitors | MAPK1, MAP3K1, MAPK3 | SMN1; SMN2 2552/4885NPC1 1932/4885ALDH1A1 1207/4885 |
| US-20030171584-A1 | Treating p38 mediated disorders such as arthritis, Crohns disease, irritable bowel syndrome adult respiratory distress syndrome or chronic obstructive pulmonary disease. | ARRB1, MAPK1, MAPK8 | SMN1; SMN2 3890/4885NPC1 4050/4885ALDH1A1 1614/4885 |
| US-20030232847-A1 | Imidazo-substituted compounds as p38 kinase inhibitors | MAPK1, MAPK3, MAP3K1 | SMN1; SMN2 2200/4885NPC1 1885/4885ALDH1A1 1032/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.