Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 11/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 1.00 |
| ▸ | NPC1 | O15118 | 7/20 | 1.00 |
| ▸ | RAB9A | P51151 | 7/20 | 1.00 |
| ▸ | TSHR | P16473 | 4/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 2/20 | 1.00 |
| ▸ | NFKB2 | Q00653 | 2/20 | 1.00 |
| ▸ | RELA | Q04206 | 2/20 | 1.00 |
| ▸ | MAPT | P10636 | 7/20 | 0.83 |
| ▸ | RECQL | P46063 | 1/20 | 0.83 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.81 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.81 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.81 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.81 |
| ▸ | LMNA | P02545 | 5/20 | 0.80 |
| ▸ | HPGD | P15428 | 2/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5120763 | 0.83 | SMN1; SMN2 (0.71) | SMN1; SMN2ALDH1A1NPC1RAB9ATSHR | |
| SCHEMBL1991090 | 0.83 | SMN1; SMN2 (0.76) | SMN1; SMN2ALDH1A1NPC1RAB9ATSHR | |
| SCHEMBL5726284 | 0.80 | ALDH1A1 (0.82) | SMN1; SMN2ALDH1A1NPC1RAB9ATSHR | |
| SCHEMBL256224 | 0.79 | ALDH1A1 (0.70) | SMN1; SMN2ALDH1A1NPC1RAB9ATSHR | |
| SCHEMBL29546526 | 0.79 | ALDH1A1 (0.70) | SMN1; SMN2ALDH1A1NPC1RAB9ATSHR | |
| SCHEMBL1808077 | 0.77 | RAB9A (0.62) | SMN1; SMN2ALDH1A1NPC1RAB9ATSHR | |
| SCHEMBL9831489 | 0.77 | NPC1 (0.77) | SMN1; SMN2ALDH1A1NPC1RAB9ATSHR | |
| SCHEMBL5262701 | 0.76 | SMN1; SMN2 (1.00) | SMN1; SMN2ALDH1A1NPC1RAB9ATSHR | |
| SCHEMBL6604256 | 0.76 | SMN1; SMN2 (0.63) | SMN1; SMN2ALDH1A1NPC1RAB9ATSHR | |
| SCHEMBL16920965 | 0.74 | SMN1; SMN2 (0.63) | SMN1; SMN2ALDH1A1NPC1RAB9ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9932300-B2 | N,N′-diarylurea compounds and N,N′-diarylthiourea compounds as inhibitors of translation initiation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2018-04-03 | — | — | US | disclosed |
| US-20160318857-A1 | N,N'-Diarylurea Compounds and N,N'-Diarylthiourea Compounds as Inhibitors of Translation Initiation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2016-11-03 | — | — | US | disclosed |
| US-9421211-B2 | N,N′-diarylurea compounds and N,N′-diarylthiourea compounds as inhibitors of translation initiation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2016-08-23 | — | — | US | disclosed |
| US-20120115915-A1 | N,N'-DIARYLUREA COMPOUNDS AND N,N'-DIARYLTHIOUREA COMPOUNDS AS INHIBITORS OF TRANSLATION INITIATION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-05-10 | — | — | US | disclosed |
| US-20110150961-A1 | ANTI-INFECTIVE CATHETERS | ANGIOTECH INTERNATIONAL AG (CH) | 2011-06-23 | — | — | US | disclosed |
| EP-2254640-A2 | ANTI-INFECTIVE CATHETERS | ANGIOTECH INTERNATIONAL AG (CH) | 2010-12-01 | — | — | EP | disclosed |
| WO-2009105484-A2 | ANTI-INFECTIVE CATHETERS | ANGIOTECH PHARMACEUTICALS, INC. (CA) | 2009-08-27 | — | — | WO | disclosed |
| US-7449581-B2 | 6-Substituted pyrido-pyrimidines | POCHE PALO ALTO LLC (US) | 2008-11-11 | — | — | US | disclosed |
| US-20070135458-A1 | 6-Substituted pyrido-pyrimidines | CHEN JIAN J | 2007-06-14 | — | — | US | disclosed |
| US-20070135458-A1 | 6-Substituted pyrido-pyrimidines | CHEN JIAN J | 2007-06-14 | — | — | US | disclosed |
| EP-1228070-B1 | HETEROALKYLAMINO-SUBSTITUTED BICYCLIC NITROGEN HETEROCYCLES AS INHIBITORS OF P38 PROTEIN KINASE | HOFFMANN LA ROCHE (CH) | 2007-02-07 | — | — | EP | disclosed |
| US-7169794-B2 | 6-substituted pyrido-pyrimidines | ROCHE PALO ALTO LLC (US) | 2007-01-30 | — | — | US | disclosed |
| US-7169794-B2 | 6-substituted pyrido-pyrimidines | ROCHE PALO ALTO LLC (US) | 2007-01-30 | — | — | US | disclosed |
| EP-1226144-B1 | ALKYLAMINO SUBSTITUTED BICYCLIC NITROGEN HETEROCYCLES AS INHIBITORS OF P38 PROTEIN KINASE | HOFFMANN LA ROCHE (CH) | 2006-12-27 | — | — | EP | disclosed |
| US-6642241-B1 | Alkylamino- substituted dihydropyrimido-(4,5-d)pyrimidinone derivatives, inhibitors of p38, | SYNTEX (U.S.A.) LLC | 2003-11-04 | — | — | US | disclosed |
| US-6451804-B1 | Heteroalkylamino-substituted bicyclic nitrogen heterocycles | SYNTEX (U.S.A.) LLC | 2002-09-17 | — | — | US | disclosed |
| EP-1228070-A1 | HETEROALKYLAMINO-SUBSTITUTED BICYCLIC NITROGEN HETEROCYCLES AS INHIBITORS OF P38 PROTEIN KINASE | F. HOFFMANN-LA ROCHE AG (CH) | 2002-08-07 | — | — | EP | disclosed |
| EP-1226144-A1 | ALKYLAMINO SUBSTITUTED BICYCLIC NITROGEN HETEROCYCLES AS INHIBITORS OF P38 PROTEIN KINASE | F. HOFFMANN-LA ROCHE AG (CH) | 2002-07-31 | — | — | EP | disclosed |
| WO-2001029041-A1 | ALKYLAMINO SUBSTITUTED BICYCLIC NITROGEN HETEROCYCLES AS INHIBITORS OF P38 PROTEIN KINASE | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-26 | — | — | WO | disclosed |
| WO-2001029042-A1 | HETEROALKYLAMINO-SUBSTITUTED BICYCLIC NITROGEN HETEROCYCLES AS INHIBITORS OF P38 PROTEIN KINASE | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160318857-A1 | N,N'-Diarylurea Compounds and N,N'-Diarylthiourea Compounds as Inhibitors of Translation Initiation | NSUN2, EIF2AK2, RNGTT | SMN1; SMN2 850/4885ALDH1A1 3464/4885NPC1 1310/4885 |
| US-20110150961-A1 | ANTI-INFECTIVE CATHETERS | NACA, PUF60, POLR1C | SMN1; SMN2 2770/4885ALDH1A1 4513/4885NPC1 4600/4885 |
| US-20070135458-A1 | 6-Substituted pyrido-pyrimidines | P2RX6, P2RX1, P2RX7 | SMN1; SMN2 2069/4885ALDH1A1 1244/4885NPC1 3852/4885 |
| US-20120115915-A1 | N,N'-DIARYLUREA COMPOUNDS AND N,N'-DIARYLTHIOUREA COMPOUNDS AS INHIBITORS OF TRANSLATION INITIATION | NSUN2, EIF2AK2, RNGTT | SMN1; SMN2 850/4885ALDH1A1 3464/4885NPC1 1310/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.