Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.66 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.59 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.54 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.54 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.54 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11830150 | 0.95 | ALOX5 (0.59) | ALOX5F2RL1CALM1ALDH1A1POLB | |
| SCHEMBL9663990 | 0.93 | ALOX5 (0.58) | ALOX5F2RL1CALM1POLB | |
| SCHEMBL925662 | 0.89 | F2RL1 (0.68) | ALOX5F2RL1CALM1ALDH1A1POLB | |
| SCHEMBL1105476 | 0.84 | ALOX5 (0.68) | ALOX5F2RL1CALM1ALDH1A1POLB | |
| SCHEMBL659052 | 0.84 | ALOX5 (0.68) | ALOX5F2RL1CALM1ALDH1A1POLB | |
| SCHEMBL503646 | 0.84 | ALOX5 (0.68) | ALOX5F2RL1CALM1ALDH1A1PLAAT3 | |
| SCHEMBL6710455 | 0.82 | ALOX5 (0.66) | ALOX5F2RL1CALM1ALDH1A1POLB | |
| SCHEMBL1274985 | 0.82 | ALOX5 (0.66) | ALOX5F2RL1CALM1ALDH1A1POLB | |
| SCHEMBL7384569 | 0.81 | ALOX5 (0.56) | ALOX5F2RL1CALM1ALDH1A1POLB | |
| SCHEMBL1239196 | 0.81 | ALOX5 (0.64) | ALOX5F2RL1CALM1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7459585-B2 | Benzene derivatives and pharmaceutical use thereof | AJINOMOTO CO., INC. (JP) | 2008-12-02 | — | — | US | disclosed |
| US-20060194854-A1 | New 2-substituted - 1,3-thiazole compounds | ASTRAZENECA AB (SE) | 2006-08-31 | — | — | US | disclosed |
| US-20050165114-A1 | Benzene derivatives and pharmaceutical use thereof | AJINOMOTO CO. INC (JP) | 2005-07-28 | — | — | US | disclosed |
| US-20050119321-A1 | 2-substituted-1,3-thiazole compounds | ASTRAZENECA AB (SE) | 2005-06-02 | — | — | US | disclosed |
| EP-1499601-A1 | NEW 2-SUBSTITUTED -1,3-THIAZOLE COMPOUNDS | AstraZeneca AB (SE) | 2005-01-26 | — | — | EP | disclosed |
| US-6703379-B2 | ANTIINFLAMMATORY AGENT, IMMUNOSUPPRESSANT, ANTICANCER AGENTS, ANTIARTHRITIC AGENTS | AJINOMOTO CO., INC. (JP) | 2004-03-09 | — | — | US | disclosed |
| WO-2003089419-A1 | NEW 2-SUBSTITUTED -1,3-THIAZOLE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-10-30 | — | — | WO | disclosed |
| US-20030166693-A1 | Benzene derivatives and pharmaceutical use thereof | AJINOMOTO CO., INC (JP) | 2003-09-04 | — | — | US | disclosed |
| US-20010018441-A1 | Benzene derivatives and Pharmaceutical use thereof | AJINOMOTO CO., INC. (JP) | 2001-08-30 | — | — | US | disclosed |
| EP-1113000-A1 | BENZENE DERIVATIVES AND MEDICINAL USE THEREOF | Ajinomoto Co., Inc. (JP) | 2001-07-04 | — | — | EP | disclosed |
| EP-0840606-B1 | DI- AND TRIVALENT SMALL MOLECULE SELECTIN INHIBITORS | TEXAS BIOTECHNOLOGY CORP (US) | 2000-06-07 | — | — | EP | disclosed |
| US-5919768-A | COMPOUNDS WHICH INHIBIT BINDING OF SELECTINS TO SIALYL-LEWIS-X AND SIALYL-LEWIS-A CARBOHYDRATES | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1999-07-06 | — | — | US | disclosed |
| EP-0446047-B1 | Benzisothiazolinone-1-dioxide derivatives as elastase inhibitors | UNILEVER PLC (GB) | 1997-06-11 | — | — | EP | disclosed |
| US-5411978-A | Aging resistance, human skin | CHESEBROUGH-POND'S USA CO., DIVISION OF CONOPCO, INC. (US) | 1995-05-02 | — | — | US | disclosed |
| US-5338747-A | Benzoisothiazolinone-1-dioxide derivatives as elastase inhibitors | CHESEBROUGH-POND'S USA CO., DIVISION OF CONOPCO, INC. (US) | 1994-08-16 | — | — | US | disclosed |
| US-5158970-A | Prolylendopeplidase inhibitors; antiamnesia | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 1992-10-27 | — | — | US | disclosed |
| CN-1056680-A | The preparation method who can be used as the 2-phenylalkanoic acid esters of human leukocytes elastase inhibitor | CORTECH INC (US) | 1991-12-04 | — | — | CN | disclosed |
| EP-0446047-A1 | Benzisothiazolinone-1-dioxide derivatives as elastase inhibitors | UNILEVER PLC (GB) | 1991-09-11 | — | — | EP | disclosed |
| EP-0384341-A2 | New proline derivatives | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 1990-08-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030166693-A1 | Benzene derivatives and pharmaceutical use thereof | NFKBIA, VCAM1, NFKB1 | ALOX5 444/4885F2RL1 818/4885CALM1 460/4885 |
| US-20060194854-A1 | New 2-substituted - 1,3-thiazole compounds | NR3C2, NR4A2, NR0B1 | ALOX5 2500/4885F2RL1 4654/4885CALM1 789/4885 |
| US-20050119321-A1 | 2-substituted-1,3-thiazole compounds | NR3C2, NR4A2, NR4A3 | ALOX5 2530/4885F2RL1 4648/4885CALM1 1222/4885 |
| US-20050165114-A1 | Benzene derivatives and pharmaceutical use thereof | NFKBIA, VCAM1, NFKB1 | ALOX5 362/4885F2RL1 803/4885CALM1 581/4885 |
| US-20010018441-A1 | Benzene derivatives and Pharmaceutical use thereof | NFKBIA, VCAM1, NFKB1 | ALOX5 444/4885F2RL1 818/4885CALM1 460/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.