Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4512232 | 1.00 | RIPK1 (0.43) | RIPK1TSHRALDH1A1GFERMAOB | |
| SCHEMBL4512234 | 1.00 | RIPK1 (0.43) | RIPK1TSHRALDH1A1GFERMAOB | |
| SCHEMBL4511699 | 0.84 | TRPA1 (0.40) | TSHRALDH1A1GFERKMT2AKDM4E | |
| SCHEMBL4511703 | 0.84 | TRPA1 (0.40) | TSHRALDH1A1GFERKMT2AKDM4E | |
| SCHEMBL4096641 | 0.84 | TRPA1 (0.40) | TSHRALDH1A1GFERKMT2AKDM4E | |
| SCHEMBL2586632 | 0.83 | L3MBTL1 (0.36) | RIPK1TSHRHTR7GRIA4 | |
| SCHEMBL2584708 | 0.80 | — | — | |
| SCHEMBL4513725 | 0.76 | ALDH1A1 (0.41) | RIPK1TSHRALDH1A1MAOBMAOA | |
| SCHEMBL4513726 | 0.76 | ALDH1A1 (0.41) | RIPK1TSHRALDH1A1MAOBMAOA | |
| SCHEMBL2584056 | 0.76 | MEN1 (0.38) | TSHRALDH1A1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1953158-B1 | BICYCLIC CINNAMIDE COMPOUND | EISAI R&D MAN CO LTD (JP) | 2012-09-12 | — | — | EP | disclosed |
| EP-1953158-A1 | BICYCLIC CINNAMIDE COMPOUND | Eisai R&D Management Co., Ltd. (JP) | 2008-08-06 | — | — | EP | disclosed |