Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM6 | O15303 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.36 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ACLY | P53396 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5112961 | 0.80 | NR1I2 (0.42) | ALDH1A1NR1I2RAB9APTPN1PTPN6 | |
| SCHEMBL5117056 | 0.74 | ALDH1A1 (0.41) | ALDH1A1NR1I2RAB9APTPN1PTPN6 | |
| SCHEMBL5128143 | 0.70 | NR1I2 (0.44) | ALDH1A1NR1I2RAB9APTPN1PTPN6 | |
| SCHEMBL2892656 | 0.65 | ALDH1A1 (0.51) | ALDH1A1RAB9APTPN1PTPN6PTPN11 | |
| SCHEMBL5283944 | 0.63 | ALDH1A1 (0.71) | ALDH1A1NR1I2RAB9APTPN1PTPN6 | |
| SCHEMBL3916479 | 0.63 | PTPN1 (0.54) | PTPN1ACLY | |
| SCHEMBL2892950 | 0.62 | ALDH1A1 (0.48) | ALDH1A1PTPN1PTPN6PTPN11MAPK1 | |
| SCHEMBL10956866 | 0.62 | NR1I2 (0.64) | ALDH1A1NR1I2PTPN1MAPK1SMN1; SMN2 | |
| SCHEMBL5286157 | 0.61 | NR1I2 (0.76) | ALDH1A1NR1I2RAB9APTPN1MAPK1 | |
| SCHEMBL28147719 | 0.61 | BMP1 (0.50) | ALDH1A1NR1I2MAPK1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080004325-A1 | PTP1B inhibitors | WYETH (US) | 2008-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080004325-A1 | PTP1B inhibitors | PTPA, PTPRJ, PTPRR | GRM6 2198/4885ALDH1A1 1266/4885NR1I2 2712/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.