SCHEMBL5125433

SCHEMBL5125433

COC1Oc2c(c(=O)oc3cc(C)ccc23)C1c1c(O)c2ccc(C)cc2oc1=O

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NQO1 P15559 5/20 0.38
MAOB P27338 2/20 0.37
CSNK2A2 P19784 1/20 0.36
CSNK2B P67870 1/20 0.36
CSNK2A1 P68400 1/20 0.36
HSD17B3 P37058 2/20 0.35
KDM4E B2RXH2 3/20 0.35
MEN1 O00255 2/20 0.35
CYP3A4 P08684 2/20 0.35
MAPT P10636 2/20 0.35
KMT2A Q03164 2/20 0.35
HPGD P15428 2/20 0.35
HSD17B10 Q99714 2/20 0.35
THRB P10828 1/20 0.35
PKM P14618 1/20 0.35
ALOX12 P18054 1/20 0.35
RECQL P46063 1/20 0.35
BLM P54132 1/20 0.35
CDC25A P30304 1/20 0.34
CDC25C P30307 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6366185 0.89 NQO1 (0.45) NQO1CSNK2A2CSNK2BCSNK2A1HSD17B3
SCHEMBL5126126 0.88 NQO1 (0.48) NQO1MAOBCSNK2A2CSNK2BCSNK2A1
SCHEMBL5115619 0.88 NQO1 (0.38) NQO1MAOBHSD17B3KDM4EMAPT
SCHEMBL5118767 0.87 HSD17B3 (0.37) NQO1MAOBHSD17B3KDM4EMAPT
SCHEMBL5114488 0.85 NQO1 (0.38) NQO1CSNK2A2CSNK2BCSNK2A1KDM4E
SCHEMBL14172399 0.85 NQO1 (0.40) NQO1MAOBHSD17B3KDM4EMEN1
SCHEMBL5337199 0.84 NQO1 (0.39) NQO1MAOBHSD17B3KDM4EMEN1
SCHEMBL5117858 0.83 NQO1 (0.46) NQO1MAOBCSNK2A2CSNK2BCSNK2A1
SCHEMBL5124909 0.81 NQO1 (0.37) NQO1MAOBKDM4EMAPTHPGD
SCHEMBL5125229 0.80 PRNP (0.42) NQO1MAOBCSNK2A2CSNK2BCSNK2A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7384975-B2 Substituted furochromenes, preparation thereof and their antiinflammatory action GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (HR) 2008-06-10 US disclosed
US-20060148889-A1 Substituted furochromenes, preparation thereof and their antiinflammatory action PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) 2006-07-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060148889-A1 Substituted furochromenes, preparation thereof and their antiinflammatory action CYP11B2, CYP11B1, LTC4S NQO1 60/4885MAOB 322/4885CSNK2A2 886/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.