Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.45 |
| ▸ | NPC1 | O15118 | 6/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3340899 | 0.91 | RAB9A (0.53) | RAB9ANPC1SMN1; SMN2MAPK14CYP2C9 | |
| SCHEMBL3340903 | 0.91 | RAB9A (0.53) | RAB9ANPC1SMN1; SMN2MAPK14CYP2C9 | |
| SCHEMBL3335167 | 0.86 | SMYD3 (0.47) | RAB9ANPC1SMN1; SMN2MAPK14CYP2C9 | |
| SCHEMBL3334272 | 0.84 | SMYD3 (0.43) | RAB9ANPC1SMN1; SMN2MAPK14MEN1 | |
| SCHEMBL3334266 | 0.82 | PIK3CA (0.42) | ALDH1A1MCHR1 | |
| SCHEMBL3332984 | 0.81 | MEN1 (0.46) | RAB9ANPC1SMN1; SMN2MAPK14CYP2C9 | |
| SCHEMBL3337490 | 0.79 | LMNA (0.44) | RAB9ANPC1SMN1; SMN2MAPK14MEN1 | |
| SCHEMBL3334542 | 0.78 | MEN1 (0.45) | RAB9ANPC1SMN1; SMN2MAPK14CYP2C9 | |
| SCHEMBL5129389 | 0.78 | BMPR1B (0.43) | MAPK14ALDH1A1LMNAHPGDTP53 | |
| SCHEMBL3336243 | 0.78 | TRIM58 (0.48) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009077-A2 | 4,6-DL- AND 2,4,6-TRISUBSTITUTED QUINAZOLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS USEFUL FOR TREATING VIRAL INFECTIONS | GILEAD SCIENCES, INC. (US) | 2008-01-24 | — | — | WO | claimed |