Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diphenhydramine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 4/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 3/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 3/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 3/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 3/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 3/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 1.00 |
| ▸ | CHRM4 | P08173 | 2/20 | 1.00 |
| ▸ | CHRM5 | P08912 | 2/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 2/20 | 1.00 |
| ▸ | ADRA2B | P18089 | 2/20 | 1.00 |
| ▸ | CHRM3 | P20309 | 2/20 | 1.00 |
| ▸ | HTR2A | P28223 | 2/20 | 1.00 |
| ▸ | HTR2C | P28335 | 2/20 | 1.00 |
| ▸ | HTR2B | P41595 | 2/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | ADRA1D | P25100 | 1/20 | 1.00 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diphenhydramine SCHEMBL1896940 | 1.00 | LMNA (1.00) | LMNACYP1A2CHRM2ADRA2ACHRM1 | |
| Diphenhydramine SCHEMBL5670807 | 1.00 | LMNA (1.00) | LMNACYP1A2CHRM2ADRA2ACHRM1 | |
| Diphenhydramine SCHEMBL7933565 | 0.99 | LMNA (0.98) | LMNACYP1A2CHRM2ADRA2ACHRM1 | |
| Diphenhydramine SCHEMBL10385770 | 0.99 | LMNA (0.98) | LMNACYP1A2CHRM2ADRA2ACHRM1 | |
| Diphenhydramine SCHEMBL28213087 | 0.97 | LMNA (0.94) | LMNACYP1A2CHRM2ADRA2ACHRM1 | |
| Diphenhydramine SCHEMBL5085363 | 0.95 | ALDH1A1 (0.91) | LMNACYP1A2CHRM2ADRA2ACHRM1 | |
| Diphenhydramine SCHEMBL8846483 | 0.94 | LMNA (0.89) | LMNACYP1A2CHRM2ADRA2ACHRM1 | |
| Diphenhydramine SCHEMBL8575800 | 0.94 | ALDH1A1 (0.88) | LMNACYP1A2CHRM2ADRA2ACHRM1 | |
| Diphenhydramine SCHEMBL19259450 | 0.94 | LMNA (0.88) | LMNACYP1A2CHRM2ADRA2ACHRM1 | |
| Diphenhydramine SCHEMBL5088309 | 0.91 | ALDH1A1 (0.83) | LMNACYP1A2CHRM2ADRA2ACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 28398 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4748537-A1 | A METHOD AND SYSTEM FOR ANALYZING A MOTION BEHAVIOR OF A ROBOT DURING A SUDDEN STOP | Siemens Industry Software Ltd. (IL) | 2026-05-27 | — | — | EP | claimed |
| EP-4734952-A1 | ORAL TABLET WITH IMPROVED UNIFORMITY OF CONTENT OF ACTIVES | Fertin Pharma A/S (DK) | 2026-05-06 | — | — | EP | claimed |
| EP-4736841-A1 | A MUCOADHESIVE LAYER FOR BUCCAL ADMINISTRATION OF AN ACTIVE PHARMACEUTICAL INGREDIENT | IQ medical GmbH (DE) | 2026-05-06 | — | — | EP | claimed |
| US-20260090966-A1 | UROLITHIN COMPOSITIONS | AMAZENTIS SA (CH) | 2026-04-02 | — | — | US | claimed |
| EP-4704971-A1 | GAMMA STIMULATION AND NEUROMODULATOR COMBINATION THERAPY | Cognito Therapeutics, Inc. (US) | 2026-03-11 | — | — | EP | claimed |
| EP-4706766-A2 | TOPICAL OPHTHALMOLOGICAL COMPOSITIONS | ADS Therapeutics LLC (US) | 2026-03-11 | — | — | EP | claimed |
| US-20260038886-A1 | SULFONE-BASED ELECTROLYTE AND SECONDARY BATTERY COMPRISING SAME | DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2026-02-05 | — | — | US | claimed |
| EP-3507371-B1 | COMPOSITIONS FOR TREATING DISEASES AND DISORDERS OF THE NERVOUS SYSTEM | UNIV RUTGERS (US) | 2026-01-28 | — | — | EP | claimed |
| EP-4673903-A1 | CONTEXTUALIZED COMMERCE SYSTEM AND METHOD FOR PROPERTY RESERVATIONS, WITH DYNAMIC PRICING | Roomer Travel Inc. (US) | 2026-01-07 | — | — | EP | claimed |
| US-12514836-B2 | Composition for prevention and treatment of myopathy | ONCOCROSS CO., LTD. (KR) | 2026-01-06 | — | — | US | claimed |
| EP-0163349-A2 | Feed circuit for an electromagnetic contactor | GHISALBA S.p.A. (IT) | 1985-12-04 | — | — | EP | claimed |
| EP-0147780-A2 | Drug delivery device | MERCK & CO. INC. (US) | 1985-07-10 | — | — | EP | claimed |
| US-4510677-A | Cases with flat terminal lugs for medium power semi-conductor components and a process for manufacturing same | THOMSON CSF (FR) | 1985-04-16 | — | — | US | claimed |
| EP-0123585-A2 | Transdermal drug form | RHONE-POULENC SANTE (FR) | 1984-10-31 | — | — | EP | claimed |
| EP-0046500-B1 | SHIFT REGISTER FOR CHECKING AND TESTING PURPOSES | IBM DEUTSCHLAND GMBH (DE) | 1983-10-05 | — | — | EP | claimed |
| US-4367356-A | Process for the production of gasoline from C4 hydrocarbons | UOP, INC. (US) | 1983-01-04 | — | — | US | claimed |
| EP-0022070-B1 | TUBULAR SUPPORTING PART FOR SMALL BUILDING STRUCTURES, WITH AT LEAST ONE CONNECTING ELEMENT DETACHABLY ASSOCIATED WITH | Schweizerische Aluminium AG (CH) | 1982-12-08 | — | — | EP | claimed |
| EP-0063070-A1 | Packages with flat terminals for medium-power semiconductor components, and method for their manufacture | THOMSON-CSF (FR) | 1982-10-20 | — | — | EP | claimed |
| US-4175119-A | Composition and method to prevent accidental and intentional overdosage with psychoactive drugs | PORTER GARRY L | 1979-11-20 | — | — | US | claimed |
| US-4007273-A | Treatment and pre-treatment of dysmetric dyslexia by improving sequential scanning and ocular fixation abilities and therapeutic compounds | LEVINSON HAROLD N | 1977-02-08 | — | — | US | claimed |