Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diphenhydramine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 2/20 | 0.88 |
| ▸ | LMNA | P02545 | 3/20 | 0.88 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.88 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.88 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.88 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.88 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.88 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.88 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.88 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.88 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.88 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.88 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.88 |
| ▸ | HTR2A | P28223 | 2/20 | 0.88 |
| ▸ | HTR2C | P28335 | 2/20 | 0.88 |
| ▸ | HTR2B | P41595 | 2/20 | 0.88 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.88 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.88 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.88 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.88 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diphenhydramine SCHEMBL1896940 | 0.94 | LMNA (1.00) | LMNACYP1A2ALDH1A1CHRM2CHRM4 | |
| Diphenhydramine SCHEMBL5670807 | 0.94 | LMNA (1.00) | LMNACYP1A2ALDH1A1CHRM2CHRM4 | |
| Diphenhydramine SCHEMBL5128 | 0.94 | LMNA (1.00) | LMNACYP1A2ALDH1A1CHRM2CHRM4 | |
| Diphenhydramine SCHEMBL5085363 | 0.93 | ALDH1A1 (0.91) | LMNACYP1A2ALDH1A1CHRM2CHRM4 | |
| Diphenhydramine SCHEMBL10385770 | 0.93 | LMNA (0.98) | LMNACYP1A2ALDH1A1CHRM2CHRM4 | |
| Diphenhydramine SCHEMBL7933565 | 0.93 | LMNA (0.98) | LMNACYP1A2ALDH1A1CHRM2CHRM4 | |
| Diphenhydramine SCHEMBL8846483 | 0.92 | LMNA (0.89) | LMNACYP1A2ALDH1A1CHRM2CHRM4 | |
| Diphenhydramine SCHEMBL8575800 | 0.91 | ALDH1A1 (0.88) | LMNACYP1A2ALDH1A1CHRM2CHRM4 | |
| Diphenhydramine SCHEMBL28213087 | 0.91 | LMNA (0.94) | LMNACYP1A2ALDH1A1CHRM2CHRM4 | |
| Diphenhydramine SCHEMBL5088309 | 0.89 | ALDH1A1 (0.83) | LMNACYP1A2ALDH1A1CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108698988-B | Process for preparing aminothiol ester compounds and salts thereof | 高级生物设计公司 | 2020-04-21 | — | — | CN | disclosed |
| US-10570089-B2 | Process for preparing aminothiol ester compounds and salts thereof | ADVANCED BIODESIGN (FR) | 2020-02-25 | — | — | US | disclosed |
| US-20190047948-A1 | PROCESS FOR PREPARING AMINOTHIOL ESTER COMPOUNDS AND SALTS THEREOF | ADVANCED BIODESIGN (FR) | 2019-02-14 | — | — | US | disclosed |
| EP-3416944-A1 | PROCESS FOR PREPARING AMINOTHIOL ESTER COMPOUNDS AND SALTS THEREOF | Advanced Biodesign (FR) | 2018-12-26 | — | — | EP | disclosed |
| WO-2017140754-A1 | PROCESS FOR PREPARING AMINOTHIOL ESTER COMPOUNDS AND SALTS THEREOF | ADVANCED BIODESIGN (FR) | 2017-08-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190047948-A1 | PROCESS FOR PREPARING AMINOTHIOL ESTER COMPOUNDS AND SALTS THEREOF | DDC, SRM, AASDHPPT | HRH1 3449/4885LMNA 1827/4885CYP1A2 1161/4885 |
| US-10570089-B2 | Process for preparing aminothiol ester compounds and salts thereof | DDC, SRM, AASDHPPT | HRH1 3449/4885LMNA 1827/4885CYP1A2 1161/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.