Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diphenhydramine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 2/20 | 0.98 |
| ▸ | LMNA | P02545 | 4/20 | 0.98 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.98 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.98 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.98 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.98 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.98 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.98 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.98 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.98 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.98 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.98 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.98 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.98 |
| ▸ | HTR2A | P28223 | 2/20 | 0.98 |
| ▸ | HTR2C | P28335 | 2/20 | 0.98 |
| ▸ | HTR2B | P41595 | 2/20 | 0.98 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.98 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.98 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diphenhydramine SCHEMBL5670807 | 0.99 | LMNA (1.00) | LMNACYP1A2CHRM2ADRA2ACHRM1 | |
| Diphenhydramine SCHEMBL1896940 | 0.99 | LMNA (1.00) | LMNACYP1A2CHRM2ADRA2ACHRM1 | |
| Diphenhydramine SCHEMBL5128 | 0.99 | LMNA (1.00) | LMNACYP1A2CHRM2ADRA2ACHRM1 | |
| Diphenhydramine SCHEMBL10385770 | 0.98 | LMNA (0.98) | LMNACYP1A2CHRM2ADRA2ACHRM1 | |
| Diphenhydramine SCHEMBL28213087 | 0.96 | LMNA (0.94) | LMNACYP1A2CHRM2ADRA2ACHRM1 | |
| Diphenhydramine SCHEMBL5085363 | 0.94 | ALDH1A1 (0.91) | LMNACYP1A2CHRM2ADRA2ACHRM1 | |
| Diphenhydramine SCHEMBL8846483 | 0.94 | LMNA (0.89) | LMNACYP1A2CHRM2ADRA2ACHRM1 | |
| Diphenhydramine SCHEMBL19259450 | 0.93 | LMNA (0.88) | LMNACYP1A2CHRM2ADRA2ACHRM1 | |
| Diphenhydramine SCHEMBL8575800 | 0.93 | ALDH1A1 (0.88) | LMNACYP1A2CHRM2ADRA2ACHRM1 | |
| Diphenhydramine SCHEMBL5088309 | 0.90 | ALDH1A1 (0.83) | LMNACYP1A2CHRM2ADRA2ACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329473-B1 | USED AS COATING FOR CRACK BRIDGING, AS AN ADHESIVE AND IN POWDER SURFACE COATINGS | SOLUTIA GERMANY GMBH & CO., KG (DE) | 2001-12-11 | — | — | US | disclosed |