Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKLR | P30613 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | BDKRB1 | P46663 | 13/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | LOX | P28300 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5128172 | 0.87 | PKLR (0.40) | PKLRCYP3A4GAACYP2C19CASP1 | |
| SCHEMBL5128085 | 0.85 | PKLR (0.50) | PKLRGAACASP1CASP3CASP7 | |
| SCHEMBL5125891 | 0.85 | PKLR (0.41) | PKLRCYP3A4GAACYP2C19CASP1 | |
| SCHEMBL5122561 | 0.84 | CCR2 (0.45) | BDKRB1CASP1CASP3CASP7CNR1 | |
| SCHEMBL5125464 | 0.84 | PKLR (0.47) | PKLRCYP3A4 | |
| SCHEMBL5131956 | 0.83 | FKBP1A (0.47) | CASP3CASP7 | |
| SCHEMBL5131432 | 0.82 | BDKRB1 (0.50) | BDKRB1CASP1CASP3CASP7CNR1 | |
| SCHEMBL3412851 | 0.81 | BDKRB1 (0.52) | PKLRCYP3A4GAACYP2C19BDKRB1 | |
| SCHEMBL5122750 | 0.81 | AVPR1A (0.47) | PKLRCNR1 | |
| SCHEMBL5132192 | 0.81 | EPHX2 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080249128-A1 | Substituted Sulfonamide Compounds | GRUENENTHAL GMBH (DE) | 2008-10-09 | — | — | US | claimed |
| US-8580965-B2 | Substituted sulfonamide compounds | GRUENENTHAL GMBH (DE) | 2013-11-12 | — | — | US | disclosed |
| US-20080249128-A1 | Substituted Sulfonamide Compounds | GRUENENTHAL GMBH (DE) | 2008-10-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080249128-A1 | Substituted Sulfonamide Compounds | BDKRB1, BDKRB2, NPSR1 | PKLR 746/4885CYP3A4 2431/4885GAA 3363/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.