Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 3/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.40 |
| ▸ | CTSA | P10619 | 6/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 3/20 | 0.36 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5125401 | 0.85 | P2RX7 (0.44) | ADORA2AADORA1KLKB1HSD17B13ALDH1A1 | |
| SCHEMBL5129241 | 0.82 | P2RX7 (0.41) | ADORA2AADORA1HSD17B13ALDH1A1MAPK1 | |
| SCHEMBL5249953 | 0.80 | P2RX7 (0.48) | HSD17B13P2RX7 | |
| SCHEMBL5129244 | 0.80 | P2RX7 (0.39) | ADORA2AADORA1HSD17B13ALDH1A1MAPK1 | |
| SCHEMBL5129254 | 0.77 | ALDH1A1 (0.47) | ALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL5128797 | 0.74 | P2RX7 (0.44) | ADORA2AADORA1ALDH1A1P2RX7 | |
| SCHEMBL5117478 | 0.74 | MEN1 (0.48) | ADORA2AADORA1ALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL5130148 | 0.73 | ALDH1A1 (0.54) | ALDH1A1MAPK1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL5121872 | 0.72 | ROCK2 (0.50) | ADORA2AALDH1A1MAPK1SMN1; SMN2MEN1 | |
| SCHEMBL5130363 | 0.71 | P2RX7 (0.48) | ALDH1A1P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7459452-B2 | Dihydroxypyrimidine carboxamide inhibitors of HIV integrase | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2008-12-02 | — | — | US | disclosed |
| US-20070083045-A1 | Dihydroxypyrimidine carboxamide inhibitors of HIV integrase | DI FRANCESCO MARIA E | 2007-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070083045-A1 | Dihydroxypyrimidine carboxamide inhibitors of HIV integrase | DUT, DPYD, TYMP | ADORA2A 1965/4885ADORA1 1036/4885CTSA 1897/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.