Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | CCR3 | P51677 | 1/20 | 0.43 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.41 |
| ▸ | CCR1 | P32246 | 1/20 | 0.41 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.40 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.40 |
| ▸ | HMGCR | P04035 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5123596 | 0.85 | LMNA (0.43) | SMN1; SMN2KCNE1CCR1KCNQ1TP53 | |
| SCHEMBL5121129 | 0.85 | KCNE1 (0.44) | SMN1; SMN2KCNE1CCR1KCNQ1TP53 | |
| SCHEMBL5120128 | 0.83 | SMN1; SMN2 (0.43) | SMN1; SMN2KCNE1CCR1KCNQ1KCNH2 | |
| SCHEMBL5115367 | 0.81 | PRKAA2 (0.47) | SMN1; SMN2KCNE1CCR1KCNQ1TP53 | |
| SCHEMBL5128153 | 0.81 | KCNE1 (0.46) | SMN1; SMN2KCNE1CCR1KCNQ1KCNH2 | |
| SCHEMBL5122853 | 0.80 | LMNA (0.42) | SMN1; SMN2KCNH2KMT2AALDH1A1LMNA | |
| SCHEMBL5122404 | 0.80 | SMN1; SMN2 (0.41) | SMN1; SMN2KCNE1CCR1KCNQ1TP53 | |
| SCHEMBL5116540 | 0.80 | KCNE1 (0.45) | SMN1; SMN2KCNE1CCR1KCNQ1KCNH2 | |
| SCHEMBL5118409 | 0.79 | TLR2 (0.42) | SMN1; SMN2KCNE1CCR1KCNQ1KCNH2 | |
| SCHEMBL5129588 | 0.79 | PRKAA2 (0.44) | SMN1; SMN2KCNE1CCR1KCNQ1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7459452-B2 | Dihydroxypyrimidine carboxamide inhibitors of HIV integrase | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2008-12-02 | — | — | US | claimed |