Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAK | O14976 | 7/20 | 0.57 |
| ▸ | RIPK2 | O43353 | 5/20 | 0.49 |
| ▸ | COQ8A | Q8NI60 | 3/20 | 0.49 |
| ▸ | NLK | Q9UBE8 | 3/20 | 0.49 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.49 |
| ▸ | EPHA8 | P29322 | 1/20 | 0.49 |
| ▸ | TXK | P42681 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.45 |
| ▸ | CYP2C8 | P10632 | 3/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 3/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5123308 | 0.88 | GAK (0.55) | GAKCYP1A2CYP2C8CYP2D6CYP2C19 | |
| SCHEMBL4829985 | 0.81 | GAK (0.57) | GAKRIPK2COQ8ANLKEPHB6 | |
| SCHEMBL5126891 | 0.81 | GAK (0.38) | GAKRIPK2COQ8ANLKEPHB6 | |
| SCHEMBL29089850 | 0.73 | GAK (0.65) | GAKRIPK2COQ8ANLKEPHB6 | |
| SCHEMBL5132193 | 0.73 | LMNA (0.51) | GAAMAPT | |
| SCHEMBL28845692 | 0.72 | FADS1 (0.66) | GAKRIPK2COQ8ANLKEPHB6 | |
| SCHEMBL29200468 | 0.71 | GAK (0.61) | GAKRIPK2COQ8ANLKEPHB6 | |
| SCHEMBL5929021 | 0.71 | MAPT (0.69) | GAKCYP1A2CYP2C8CYP2D6CYP2C19 | |
| SCHEMBL29200458 | 0.70 | GAK (0.64) | GAKRIPK2COQ8ANLKEPHB6 | |
| SCHEMBL29200480 | 0.70 | GAK (0.57) | GAKRIPK2COQ8ANLKEPHB6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080004312-A1 | Pyridine, pyrimidine, quinoline, quinazoline, and naphthalene urotensin-II receptor antagonists | ENCYSIVE PHARMACEUTICALS, INC. | 2008-01-03 | — | — | US | disclosed |
| US-20050054850-A1 | Pyridine, pyrimidine, quinoline, quinazoline, and naphthalene urotensin-II receptor antagonists | ENCYSIVE PHARMACEUTICALS INC. | 2005-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050054850-A1 | Pyridine, pyrimidine, quinoline, quinazoline, and naphthalene urotensin-II receptor antagonists | UTS2R, GPR17, NTSR2 | GAK 2544/4885RIPK2 1307/4885COQ8A 546/4885 |
| US-20080004312-A1 | Pyridine, pyrimidine, quinoline, quinazoline, and naphthalene urotensin-II receptor antagonists | UTS2R, GPR17, NTSR2 | GAK 2544/4885RIPK2 1307/4885COQ8A 546/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.