Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | CETP | P11597 | 1/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.45 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.45 |
| ▸ | KIF11 | P52732 | 1/20 | 0.44 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24749809 | 0.86 | TDP1 (0.47) | KMT2AMAPTALDH1A1MEN1CETP | |
| SCHEMBL29149364 | 0.81 | ALDH1A1 (0.47) | KMT2AMAPTALDH1A1MEN1HTT | |
| SCHEMBL3781829 | 0.81 | HTR2A (0.41) | MAPTALDH1A1TDP1LMNAL3MBTL1 | |
| SCHEMBL8964829 | 0.79 | TDP1 (0.62) | CYP19A1KMT2AMAPTALDH1A1MEN1 | |
| SCHEMBL10796106 | 0.78 | MEN1 (0.57) | KMT2AMAPTALDH1A1MEN1KIF11 | |
| SCHEMBL2130393 | 0.76 | CTSD (0.48) | KMT2AMAPTALDH1A1MEN1HTT | |
| SCHEMBL11815247 | 0.76 | MPO (0.56) | KMT2AMAPTALDH1A1MEN1KIF11 | |
| SCHEMBL3780422 | 0.76 | KMT2A (0.44) | KMT2AMAPTALDH1A1MEN1HTT | |
| SCHEMBL3766633 | 0.74 | POLB (0.60) | MAPTHTTTDP1LMNASMN1; SMN2 | |
| SCHEMBL12172741 | 0.74 | MRGPRX4 (0.58) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2443092-B1 | BICYCLIC AND TRICYCLIC COMPOUNDS AS KAT II INHIBITORS | PFIZER (US) | 2015-04-08 | — | — | EP | disclosed |
| US-8183238-B2 | Bicyclic and tricyclic compounds as KAT II inhibitors | PFIZER INC. (US) | 2012-05-22 | — | — | US | disclosed |