Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 2/20 | 0.39 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | FABP4 | P15090 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 4/20 | 0.36 |
| ▸ | PPARD | Q03181 | 4/20 | 0.36 |
| ▸ | PPARA | Q07869 | 4/20 | 0.36 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.35 |
| ▸ | LPAR5 | Q9H1C0 | 3/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.35 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.35 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5128413 | 0.91 | MTNR1A (0.39) | MTNR1AMTNR1BSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2979319 | 0.91 | KMT2A (0.48) | PTGER4PTGER2TSHRMTNR1AMTNR1B | |
| SCHEMBL5126359 | 0.84 | PPARA (0.47) | PPARGPPARDPPARAPTGDR2PTGDR | |
| SCHEMBL2991813 | 0.82 | SLC6A4 (0.48) | MTNR1AMTNR1BSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5132543 | 0.81 | SLC6A4 (0.40) | MTNR1AMTNR1BSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2975710 | 0.75 | LMNA (0.46) | SLC6A2SLC6A4SLC6A3KMT2APTGDR2 | |
| SCHEMBL2990233 | 0.75 | LPAR1 (0.49) | PTGER4PTGER2MTNR1AMTNR1BLPAR1 | |
| SCHEMBL2979962 | 0.74 | LOXL2 (0.46) | MTNR1AMTNR1BSLC6A2SLC6A4KMT2A | |
| SCHEMBL5128416 | 0.74 | SLC6A4 (0.43) | MTNR1AMTNR1BSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2983606 | 0.72 | PPARA (0.49) | PPARGPPARDPPARAPTGDR2PTGDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8492437-B2 | 4-substituted phenoxyphenylacetic acid derivatives | ARRAY BIOPHARMA INC. (US) | 2013-07-23 | — | — | US | disclosed |
| EP-2057115-B9 | 4-SUBSTITUTED PHENOXYPHENYLACETIC ACID DERIVATIVES | ARRAY BIOPHARMA INC (US) | 2012-12-26 | — | — | EP | disclosed |
| EP-2057115-B1 | 4-SUBSTITUTED PHENOXYPHENYLACETIC ACID DERIVATIVES | ARRAY BIOPHARMA INC (US) | 2012-10-03 | — | — | EP | disclosed |
| US-8183289-B2 | 4-substituted phenoxyphenylacetic acid derivatives | ARRAY BIOPHARMA INC. (US) | 2012-05-22 | — | — | US | disclosed |