Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 8/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CPT2 | P23786 | 3/20 | 0.37 |
| ▸ | CPT1A | P50416 | 3/20 | 0.37 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | CCR6 | P51684 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL391788 | 0.89 | CETP (0.44) | USP30GPR119CPT2CPT1AFFAR1 | |
| SCHEMBL389149 | 0.88 | CETP (0.44) | USP30GPR119CCR6 | |
| SCHEMBL386184 | 0.88 | GPR119 (0.54) | USP30GPR119TBK1 | |
| SCHEMBL28766879 | 0.85 | GPR119 (0.39) | USP30GPR119ALDH1A1SPHK1CCR6 | |
| SCHEMBL4521480 | 0.82 | ALDH1A1 (0.43) | USP30ALDH1A1KCNH2 | |
| SCHEMBL4655448 | 0.81 | S1PR1 (0.53) | TBK1S1PR1 | |
| SCHEMBL27657417 | 0.81 | USP30 (0.38) | USP30ALDH1A1CPT2CPT1ASPHK1 | |
| SCHEMBL1069804 | 0.80 | GPR119 (0.33) | GPR119ALDH1A1CPT2CPT1ATBK1 | |
| SCHEMBL14640963 | 0.79 | ROCK2 (0.45) | CPT2CPT1ATBK1S1PR1 | |
| SCHEMBL5134354 | 0.78 | SCD (0.33) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004157-A2 | USE OF GPR119 RECEPTOR AGONISTS FOR INCREASING BONE MASS AND FOR TREATING OSTEOPOROSIS, AS WELL AS COMBINATION THERAPY RELATING THERETO | Arena Pharmaceuticals, Inc. (US) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007120702-A2 | USE OF GPR119 RECEPTOR AGONISTS FOR INCREASING BONE MASS AND FOR TREATING OSTEOPOROSIS, AND COMBINATION THERAPY RELATING THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2007-10-25 | — | — | WO | disclosed |