Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | RIPK3 | Q9Y572 | 3/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 6/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.34 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.34 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.34 |
| ▸ | MOGAT2 | Q3SYC2 | 1/20 | 0.34 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.34 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | PKLR | P30613 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4976851 | 0.87 | TRAP1 (0.39) | CYP1A2MAPTCYP2C19KMT2AAKR1B1 | |
| SCHEMBL5135639 | 0.78 | AKR1B1 (0.38) | DAOCYP1A2MAPTCYP2C19KMT2A | |
| SCHEMBL3957233 | 0.71 | CYP1A2 (0.39) | CYP1A2MAPTCYP2C19KMT2AAKR1B1 | |
| SCHEMBL3950564 | 0.71 | CYP1A2 (0.43) | CYP1A2MAPTCYP2C19KMT2AAKR1B1 | |
| SCHEMBL4979292 | 0.71 | CYP1A2 (0.43) | CYP1A2MAPTCYP2C19KMT2AAKR1B1 | |
| SCHEMBL4977915 | 0.69 | KDM4E (0.42) | CYP1A2MAPTCYP2C19KMT2A | |
| SCHEMBL4263802 | 0.68 | AKR1B1 (0.43) | AKR1B1AKR1B10AKR1A1 | |
| SCHEMBL3952569 | 0.68 | OPRM1 (0.44) | CYP1A2MAPTCYP2C19KMT2AAKR1B1 | |
| SCHEMBL4976847 | 0.65 | TRAP1 (0.39) | CYP1A2MAPTCYP2C19KMT2AAKR1B1 | |
| SCHEMBL27634838 | 0.64 | IDO1 (0.58) | DAOIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984374-A1 | USE OF SPIRO Ý IMIDAZOLIDINE-4, 3'-INDOLE¨2, 2', 5' (1H) TRIONES FOR TREATMENT OF CONDITIONS ASSOCIATED WITH VANILLOID RECEPTOR 1 | AstraZeneca AB (SE) | 2008-10-29 | — | — | EP | claimed |
| WO-2007091946-A1 | USE OF SPIRO [ IMIDAZOLIDINE-4, 3'-INDOLE] 2, 2', 5' (1H) TRIONES FOR TREATMENT OF CONDITIONS ASSOCIATED WITH VANILLOID RECEPTOR 1 | ASTRAZENECA AB (SE) | 2007-08-16 | — | — | WO | claimed |